Herb formula "Fufangqishe-Pill" prevents upright posture-induced intervertebral disc degeneration at the lumbar in rats

Qian Qian Liang; Zhi Jie Xi; Qin Bian; Xue Jun Cui; Chen Guang Li; Wei Hou; Qi Shi; Yong Jun Wang

doi:10.1254/jphs.09231FP

Herb formula "Fufangqishe-Pill" prevents upright posture-induced intervertebral disc degeneration at the lumbar in rats

Qian Qian Liang, Zhi Jie Xi, Qin Bian, Xue Jun Cui, Chen Guang Li, Wei Hou, Qi Shi, Yong Jun Wang

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Degeneration of the lumbar spine plays an important role in most chronic low back pain. Prevention of lumbar intervertebral disc (IVD) degeneration is therefore a high research priority. Both our previous multicenter clinical trials and pharmacological research showed that Fufangqishe-Pill (FFQSP), a newly patented traditional Chinese medicine, could effectively relieve the symptoms of neck pain and prevent cervical degeneration. To clarify the effect of FFQSP on lumbar IVD degeneration, we applied a lumbar IVD degeneration rat model induced by prolonged upright posture. Pretreatment of FFQSP for one month prevented the histological changes indicating IVD disorganization; increased type II-collagen level, decreased type X-collagen protein level, and increased Col2α1 mRNA expression at all time points; and decreased Col10α1, matrix metalloproteinase (MMP)-3, MMP13, and Interleukin (IL)-1β mRNA expression induced by upright posture for 7 and 9 months. These results suggest that FFQSP prevents lumbar IVD degeneration induced by upright posture. FFQSP is a promising medicine for lumbar IVD degeneration disease.

Original language	English (US)
Pages (from-to)	23-31
Number of pages	9
Journal	Journal of Pharmacological Sciences
Volume	113
Issue number	1
DOIs	https://doi.org/10.1254/jphs.09231FP
State	Published - May 17 2010
Externally published	Yes

Keywords

Chronic low back pain
Extracellular matrix
Fufangqishe-Pill
Lumbar intervertebral disc degeneration

ASJC Scopus subject areas

Molecular Medicine
Pharmacology

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title = "Herb formula {"}Fufangqishe-Pill{"} prevents upright posture-induced intervertebral disc degeneration at the lumbar in rats",

abstract = "Degeneration of the lumbar spine plays an important role in most chronic low back pain. Prevention of lumbar intervertebral disc (IVD) degeneration is therefore a high research priority. Both our previous multicenter clinical trials and pharmacological research showed that Fufangqishe-Pill (FFQSP), a newly patented traditional Chinese medicine, could effectively relieve the symptoms of neck pain and prevent cervical degeneration. To clarify the effect of FFQSP on lumbar IVD degeneration, we applied a lumbar IVD degeneration rat model induced by prolonged upright posture. Pretreatment of FFQSP for one month prevented the histological changes indicating IVD disorganization; increased type II-collagen level, decreased type X-collagen protein level, and increased Col2α1 mRNA expression at all time points; and decreased Col10α1, matrix metalloproteinase (MMP)-3, MMP13, and Interleukin (IL)-1β mRNA expression induced by upright posture for 7 and 9 months. These results suggest that FFQSP prevents lumbar IVD degeneration induced by upright posture. FFQSP is a promising medicine for lumbar IVD degeneration disease.",

keywords = "Chronic low back pain, Extracellular matrix, Fufangqishe-Pill, Lumbar intervertebral disc degeneration",

author = "Liang, {Qian Qian} and Xi, {Zhi Jie} and Qin Bian and Cui, {Xue Jun} and Li, {Chen Guang} and Wei Hou and Qi Shi and Wang, {Yong Jun}",

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doi = "10.1254/jphs.09231FP",

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T1 - Herb formula "Fufangqishe-Pill" prevents upright posture-induced intervertebral disc degeneration at the lumbar in rats

AU - Liang, Qian Qian

AU - Xi, Zhi Jie

AU - Bian, Qin

AU - Cui, Xue Jun

AU - Li, Chen Guang

AU - Hou, Wei

AU - Shi, Qi

AU - Wang, Yong Jun

PY - 2010/5/17

Y1 - 2010/5/17

N2 - Degeneration of the lumbar spine plays an important role in most chronic low back pain. Prevention of lumbar intervertebral disc (IVD) degeneration is therefore a high research priority. Both our previous multicenter clinical trials and pharmacological research showed that Fufangqishe-Pill (FFQSP), a newly patented traditional Chinese medicine, could effectively relieve the symptoms of neck pain and prevent cervical degeneration. To clarify the effect of FFQSP on lumbar IVD degeneration, we applied a lumbar IVD degeneration rat model induced by prolonged upright posture. Pretreatment of FFQSP for one month prevented the histological changes indicating IVD disorganization; increased type II-collagen level, decreased type X-collagen protein level, and increased Col2α1 mRNA expression at all time points; and decreased Col10α1, matrix metalloproteinase (MMP)-3, MMP13, and Interleukin (IL)-1β mRNA expression induced by upright posture for 7 and 9 months. These results suggest that FFQSP prevents lumbar IVD degeneration induced by upright posture. FFQSP is a promising medicine for lumbar IVD degeneration disease.

AB - Degeneration of the lumbar spine plays an important role in most chronic low back pain. Prevention of lumbar intervertebral disc (IVD) degeneration is therefore a high research priority. Both our previous multicenter clinical trials and pharmacological research showed that Fufangqishe-Pill (FFQSP), a newly patented traditional Chinese medicine, could effectively relieve the symptoms of neck pain and prevent cervical degeneration. To clarify the effect of FFQSP on lumbar IVD degeneration, we applied a lumbar IVD degeneration rat model induced by prolonged upright posture. Pretreatment of FFQSP for one month prevented the histological changes indicating IVD disorganization; increased type II-collagen level, decreased type X-collagen protein level, and increased Col2α1 mRNA expression at all time points; and decreased Col10α1, matrix metalloproteinase (MMP)-3, MMP13, and Interleukin (IL)-1β mRNA expression induced by upright posture for 7 and 9 months. These results suggest that FFQSP prevents lumbar IVD degeneration induced by upright posture. FFQSP is a promising medicine for lumbar IVD degeneration disease.

KW - Chronic low back pain

KW - Extracellular matrix

KW - Fufangqishe-Pill

KW - Lumbar intervertebral disc degeneration

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Herb formula "Fufangqishe-Pill" prevents upright posture-induced intervertebral disc degeneration at the lumbar in rats

Abstract

Keywords

ASJC Scopus subject areas

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