Herb formula "Fufangqishe-Pill" prevents upright posture-induced intervertebral disc degeneration at the lumbar in rats

Qian Qian Liang, Zhi Jie Xi, Qin Bian, Xue Jun Cui, Chen Guang Li, Wei Hou, Qi Shi, Yong Jun Wang

Research output: Contribution to journalArticle

Abstract

Degeneration of the lumbar spine plays an important role in most chronic low back pain. Prevention of lumbar intervertebral disc (IVD) degeneration is therefore a high research priority. Both our previous multicenter clinical trials and pharmacological research showed that Fufangqishe-Pill (FFQSP), a newly patented traditional Chinese medicine, could effectively relieve the symptoms of neck pain and prevent cervical degeneration. To clarify the effect of FFQSP on lumbar IVD degeneration, we applied a lumbar IVD degeneration rat model induced by prolonged upright posture. Pretreatment of FFQSP for one month prevented the histological changes indicating IVD disorganization; increased type II-collagen level, decreased type X-collagen protein level, and increased Col2α1 mRNA expression at all time points; and decreased Col10α1, matrix metalloproteinase (MMP)-3, MMP13, and Interleukin (IL)-1β mRNA expression induced by upright posture for 7 and 9 months. These results suggest that FFQSP prevents lumbar IVD degeneration induced by upright posture. FFQSP is a promising medicine for lumbar IVD degeneration disease.

Original languageEnglish (US)
Pages (from-to)23-31
Number of pages9
JournalJournal of Pharmacological Sciences
Volume113
Issue number1
DOIs
StatePublished - May 17 2010

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Keywords

  • Chronic low back pain
  • Extracellular matrix
  • Fufangqishe-Pill
  • Lumbar intervertebral disc degeneration

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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