Herb formula "Fufangqishe-Pill" prevents upright posture-induced intervertebral disc degeneration at the lumbar in rats

Qian Qian Liang, Zhi Jie Xi, Qin Bian, Xue Jun Cui, Chen Guang Li, Wei Hou, Qi Shi, Yong Jun Wang

Research output: Contribution to journalArticle

Abstract

Degeneration of the lumbar spine plays an important role in most chronic low back pain. Prevention of lumbar intervertebral disc (IVD) degeneration is therefore a high research priority. Both our previous multicenter clinical trials and pharmacological research showed that Fufangqishe-Pill (FFQSP), a newly patented traditional Chinese medicine, could effectively relieve the symptoms of neck pain and prevent cervical degeneration. To clarify the effect of FFQSP on lumbar IVD degeneration, we applied a lumbar IVD degeneration rat model induced by prolonged upright posture. Pretreatment of FFQSP for one month prevented the histological changes indicating IVD disorganization; increased type II-collagen level, decreased type X-collagen protein level, and increased Col2α1 mRNA expression at all time points; and decreased Col10α1, matrix metalloproteinase (MMP)-3, MMP13, and Interleukin (IL)-1β mRNA expression induced by upright posture for 7 and 9 months. These results suggest that FFQSP prevents lumbar IVD degeneration induced by upright posture. FFQSP is a promising medicine for lumbar IVD degeneration disease.

Original languageEnglish (US)
Pages (from-to)23-31
Number of pages9
JournalJournal of Pharmacological Sciences
Volume113
Issue number1
DOIs
StatePublished - May 17 2010
Externally publishedYes

Fingerprint

Intervertebral Disc Degeneration
Posture
Collagen Type X
Matrix Metalloproteinase 3
Messenger RNA
Collagen Type II
Neck Pain
Intervertebral Disc
Chinese Traditional Medicine
Low Back Pain
Interleukin-1
Research
Multicenter Studies
Spine
fufangqishe-pill
Clinical Trials
Pharmacology
Proteins

Keywords

  • Chronic low back pain
  • Extracellular matrix
  • Fufangqishe-Pill
  • Lumbar intervertebral disc degeneration

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Herb formula "Fufangqishe-Pill" prevents upright posture-induced intervertebral disc degeneration at the lumbar in rats. / Liang, Qian Qian; Xi, Zhi Jie; Bian, Qin; Cui, Xue Jun; Li, Chen Guang; Hou, Wei; Shi, Qi; Wang, Yong Jun.

In: Journal of Pharmacological Sciences, Vol. 113, No. 1, 17.05.2010, p. 23-31.

Research output: Contribution to journalArticle

Liang, Qian Qian ; Xi, Zhi Jie ; Bian, Qin ; Cui, Xue Jun ; Li, Chen Guang ; Hou, Wei ; Shi, Qi ; Wang, Yong Jun. / Herb formula "Fufangqishe-Pill" prevents upright posture-induced intervertebral disc degeneration at the lumbar in rats. In: Journal of Pharmacological Sciences. 2010 ; Vol. 113, No. 1. pp. 23-31.
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