Heptaspanning membrane receptors and cytoskeletal/scaffolding proteins: Focus on adenosine, dopamine, and metabotropic glutamate receptor function

Francisco Ciruela, Laia Canela, Javier Burgueño, Ana Soriguera, Nuria Cabello, Enric I. Canela, Vicent Casadó, Antonio Cortés, Josefa Mallol, Amina S. Woods, Sergi Ferré, Carmen Lluis, Rafael Franco

Research output: Contribution to journalArticle

Abstract

Most cellular functions are mediated by multiprotein complexes. In neurons, these complexes are directly involved in the proper neuronal transmission, which is responsible for phenomena like learning, memory, and development. In recent years studies based on two-hybrid screens and proteomic, biochemical, and cell biology approaches have shown that intracellular domains of G protein-coupled receptors (GPCRs) or heptaspanning membrane receptors (HSMRs) interact with intracellular proteins. These interactions are the basis of a protein network associated with these receptors, which includes scaffolding proteins containing one or several PDZ (post-synaptic-density-95/discs-large/ zona occludens-1) domains, signaling proteins, and proteins of the cytoskeleton. The present article is focused on the emerging evidence for interactions of adenosine, dopamine, and metabotropic glutamate receptors, with scaffolding and cytoskeletal proteins that play a role in the targeting and anchoring of these receptors to the plasma membrane, thus contributing to neuronal development and plasticity. Finally, given the complexity of neurological disorders such as ischemic stroke, Alzheimer's disease, and epilepsy, exploitation of these HSMR-associated interactions might prove to be efficient in the treatment of such disorders.

Original languageEnglish (US)
Pages (from-to)277-292
Number of pages16
JournalJournal of Molecular Neuroscience
Volume26
Issue number2-3
DOIs
StatePublished - Jun 2005
Externally publishedYes

Keywords

  • Adenosine
  • Dopamine
  • Glutamate
  • GPCR
  • Protein-protein interaction

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry
  • Genetics

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    Ciruela, F., Canela, L., Burgueño, J., Soriguera, A., Cabello, N., Canela, E. I., Casadó, V., Cortés, A., Mallol, J., Woods, A. S., Ferré, S., Lluis, C., & Franco, R. (2005). Heptaspanning membrane receptors and cytoskeletal/scaffolding proteins: Focus on adenosine, dopamine, and metabotropic glutamate receptor function. Journal of Molecular Neuroscience, 26(2-3), 277-292. https://doi.org/10.1385/JMN:26:2-3:277