Hepcidin Bound to α2-Macroglobulin Reduces Ferroportin-1 Expression and Enhances Its Activity at Reducing Serum Iron Levels

Michael Li Hsuan Huang, Christopher J.D. Austin, Marie Agnès Sari, Yohan Suryo Rahmanto, Prem Ponka, Daniel Vyoral, Des R. Richardson

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Hepcidin is the hormone of iron metabolism that is bound by α2-macroglobulin (α2M) and its activated counterpart (α2M-MA). Results: Serum iron is reduced to a greater extent in mice treated with α2M·hepcidin or α2M-MA·hepcidin relative to unbound hepcidin. Conclusion: α2M retards hepcidin excretion by the kidney, increasing its efficacy. Significance: These results are important for understanding hepcidin transport and detection in blood.

Original languageEnglish (US)
Pages (from-to)25450-25465
Number of pages16
JournalJournal of Biological Chemistry
Volume288
Issue number35
DOIs
StatePublished - Aug 30 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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