TY - JOUR
T1 - Hepcidin Bound to α2-Macroglobulin Reduces Ferroportin-1 Expression and Enhances Its Activity at Reducing Serum Iron Levels
AU - Huang, Michael Li Hsuan
AU - Austin, Christopher J.D.
AU - Sari, Marie Agnès
AU - Rahmanto, Yohan Suryo
AU - Ponka, Prem
AU - Vyoral, Daniel
AU - Richardson, Des R.
PY - 2013/8/30
Y1 - 2013/8/30
N2 - Background: Hepcidin is the hormone of iron metabolism that is bound by α2-macroglobulin (α2M) and its activated counterpart (α2M-MA). Results: Serum iron is reduced to a greater extent in mice treated with α2M·hepcidin or α2M-MA·hepcidin relative to unbound hepcidin. Conclusion: α2M retards hepcidin excretion by the kidney, increasing its efficacy. Significance: These results are important for understanding hepcidin transport and detection in blood.
AB - Background: Hepcidin is the hormone of iron metabolism that is bound by α2-macroglobulin (α2M) and its activated counterpart (α2M-MA). Results: Serum iron is reduced to a greater extent in mice treated with α2M·hepcidin or α2M-MA·hepcidin relative to unbound hepcidin. Conclusion: α2M retards hepcidin excretion by the kidney, increasing its efficacy. Significance: These results are important for understanding hepcidin transport and detection in blood.
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U2 - 10.1074/jbc.M113.471573
DO - 10.1074/jbc.M113.471573
M3 - Article
C2 - 23846698
AN - SCOPUS:84883380705
SN - 0021-9258
VL - 288
SP - 25450
EP - 25465
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 35
ER -