Hepatotoxicity of the daily combination of 5 mg/kg prothionamide + 10 mg/kg rifampin

J. L. Cartel, Y. Naudillon, J. C. Artus, J. H. Grosset

Research output: Contribution to journalArticle

Abstract

Because a 13% incidence of hepatotoxicity was observed in a first study of multibacillary leprosy patients treated daily with dapsone, rifampin, and 10 mg/kg thioamide, the patients were treated in a second study with 5 mg/kg thioamide in daily combination with dapsone and rifampin. In this study, monthly assessments of liver function were performed in order to detect early hepatic disturbances. Despite the reduced dosage of thioamide, a 16.5% incidence of hepatotoxicity was observed among 110 multibacillary patients. However, jaundice was observed in only 2 out of 18 cases of hepatotoxicity (11%); whereas it was observed in 5 out of the 7 cases of hepatotoxicity (71%) in the first study (p < 0.05). The decrease in the thioamide dosage and the performance of monthly assessments of liver function did not decrease the incidence of hepatotoxicity but did decrease its severity. It is concluded that thioamide should not be used in daily combination with rifampin unless the daily dose is 5 mg/kg and monthly assessments of liver function are routinely performed.

Original languageEnglish (US)
Pages (from-to)15-18
Number of pages4
JournalInternational Journal of Leprosy
Volume53
Issue number1
StatePublished - Jan 1 1985

ASJC Scopus subject areas

  • Dermatology

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    Cartel, J. L., Naudillon, Y., Artus, J. C., & Grosset, J. H. (1985). Hepatotoxicity of the daily combination of 5 mg/kg prothionamide + 10 mg/kg rifampin. International Journal of Leprosy, 53(1), 15-18.