Hepatotoxic doses of dioxin do not damage mouse bone marrow chromosomes

J. Meyne; D. C. Allison; K. Bose; S. W. Jordan; P. F. Ridolpho; J. Smith

doi:10.1016/0165-1218(85)90050-3

Hepatotoxic doses of dioxin do not damage mouse bone marrow chromosomes

J. Meyne, D. C. Allison, K. Bose, S. W. Jordan, P. F. Ridolpho, J. Smith

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

We report on a study of the cytogenetic and hepatotoxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Mice of the C57B1/6J (with high-affinity TCDD receptor) or DBA/2J (with low-affinity TCDD receptor) strains were given single intraperitoneal injections of 50, 100 or 150 μg of TCDD/kg body weight. At various times (8-48 h) after injection, we examined bone marrow cells for cytogenetic effects by performing structural aberration, sister-chromatid exchange, and micronucleus tests. 1 month after exposure, liver sections were studied for hepatotoxic effects. We found no evidence of chromosome damage by TCDD given in doses that cause liver damage in both strains of mice.

Original language	English (US)
Pages (from-to)	63-69
Number of pages	7
Journal	Mutation Research/Genetic Toxicology
Volume	157
Issue number	1
DOIs	https://doi.org/10.1016/0165-1218(85)90050-3
State	Published - Jul 1985
Externally published	Yes

ASJC Scopus subject areas

Toxicology
Genetics

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@article{bd523e3057534e4c987b85797789def4,

title = "Hepatotoxic doses of dioxin do not damage mouse bone marrow chromosomes",

abstract = "We report on a study of the cytogenetic and hepatotoxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Mice of the C57B1/6J (with high-affinity TCDD receptor) or DBA/2J (with low-affinity TCDD receptor) strains were given single intraperitoneal injections of 50, 100 or 150 μg of TCDD/kg body weight. At various times (8-48 h) after injection, we examined bone marrow cells for cytogenetic effects by performing structural aberration, sister-chromatid exchange, and micronucleus tests. 1 month after exposure, liver sections were studied for hepatotoxic effects. We found no evidence of chromosome damage by TCDD given in doses that cause liver damage in both strains of mice.",

author = "J. Meyne and Allison, {D. C.} and K. Bose and Jordan, {S. W.} and Ridolpho, {P. F.} and J. Smith",

note = "Funding Information: * Supported by the Veteran's Administration. Correspondence to: Dr. David C. Allison, Department of Surgery, Albuquerque VAMC, 2100 Ridgecrest Dr SE, Albuquerque, NM 87108, U.S.A.",

year = "1985",

month = jul,

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language = "English (US)",

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T1 - Hepatotoxic doses of dioxin do not damage mouse bone marrow chromosomes

AU - Meyne, J.

AU - Allison, D. C.

AU - Bose, K.

AU - Jordan, S. W.

AU - Ridolpho, P. F.

AU - Smith, J.

N1 - Funding Information: * Supported by the Veteran's Administration. Correspondence to: Dr. David C. Allison, Department of Surgery, Albuquerque VAMC, 2100 Ridgecrest Dr SE, Albuquerque, NM 87108, U.S.A.

PY - 1985/7

Y1 - 1985/7

N2 - We report on a study of the cytogenetic and hepatotoxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Mice of the C57B1/6J (with high-affinity TCDD receptor) or DBA/2J (with low-affinity TCDD receptor) strains were given single intraperitoneal injections of 50, 100 or 150 μg of TCDD/kg body weight. At various times (8-48 h) after injection, we examined bone marrow cells for cytogenetic effects by performing structural aberration, sister-chromatid exchange, and micronucleus tests. 1 month after exposure, liver sections were studied for hepatotoxic effects. We found no evidence of chromosome damage by TCDD given in doses that cause liver damage in both strains of mice.

AB - We report on a study of the cytogenetic and hepatotoxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Mice of the C57B1/6J (with high-affinity TCDD receptor) or DBA/2J (with low-affinity TCDD receptor) strains were given single intraperitoneal injections of 50, 100 or 150 μg of TCDD/kg body weight. At various times (8-48 h) after injection, we examined bone marrow cells for cytogenetic effects by performing structural aberration, sister-chromatid exchange, and micronucleus tests. 1 month after exposure, liver sections were studied for hepatotoxic effects. We found no evidence of chromosome damage by TCDD given in doses that cause liver damage in both strains of mice.

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JO - Mutation Research/Genetic Toxicology

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IS - 1

ER -

Hepatotoxic doses of dioxin do not damage mouse bone marrow chromosomes

Abstract

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