Hepatotoxic doses of dioxin do not damage mouse bone marrow chromosomes

J. Meyne, D. C. Allison, K. Bose, S. W. Jordan, P. F. Ridolpho, J. Smith

Research output: Contribution to journalArticle

Abstract

We report on a study of the cytogenetic and hepatotoxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Mice of the C57B1/6J (with high-affinity TCDD receptor) or DBA/2J (with low-affinity TCDD receptor) strains were given single intraperitoneal injections of 50, 100 or 150 μg of TCDD/kg body weight. At various times (8-48 h) after injection, we examined bone marrow cells for cytogenetic effects by performing structural aberration, sister-chromatid exchange, and micronucleus tests. 1 month after exposure, liver sections were studied for hepatotoxic effects. We found no evidence of chromosome damage by TCDD given in doses that cause liver damage in both strains of mice.

Original languageEnglish (US)
Pages (from-to)63-69
Number of pages7
JournalMutation Research/Genetic Toxicology
Volume157
Issue number1
DOIs
StatePublished - Jul 1985

ASJC Scopus subject areas

  • Toxicology
  • Genetics

Fingerprint Dive into the research topics of 'Hepatotoxic doses of dioxin do not damage mouse bone marrow chromosomes'. Together they form a unique fingerprint.

  • Cite this

    Meyne, J., Allison, D. C., Bose, K., Jordan, S. W., Ridolpho, P. F., & Smith, J. (1985). Hepatotoxic doses of dioxin do not damage mouse bone marrow chromosomes. Mutation Research/Genetic Toxicology, 157(1), 63-69. https://doi.org/10.1016/0165-1218(85)90050-3