Hepatorenal syndrome

Sharon Turban, Paul J. Thuluvath, Mohamed G. Atta

Research output: Contribution to journalReview articlepeer-review

Abstract

Hepatorenal syndrome (HRS) is a "functional" and reversible form of renal failure that occurs in patients with advanced chronic liver disease. The distinctive hallmark feature of HRS is the intense renal vasoconstriction caused by interactions between systemic and portal hemodynamics. This results in activation of vasoconstrictors and suppression of vasodilators in the renal circulation. Epidemiology, pathophysiology, as well as current and emerging therapies of HRS are discussed in this review.

Original languageEnglish (US)
Pages (from-to)4046-4055
Number of pages10
JournalWorld Journal of Gastroenterology
Volume13
Issue number30
DOIs
StatePublished - Aug 14 2007

Keywords

  • Acute renal failure
  • Dialysis
  • End stage liver disease
  • Hepatorenal syndrome
  • Liver transplantation
  • Transjugular intrahepatic portosystemic shunts

ASJC Scopus subject areas

  • Gastroenterology

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