Hepatoma derived growth factor is a nuclear targeted mitogen

Allen D Everett, John Bushweleer

Research output: Contribution to journalArticle

Abstract

Hepatoma Derived Growth Factor (HDGF) was originally identified as a secreted mitogen from the human hepatoma cell line Huh-7. Although initially thought to be a cytoplasmic protein, it became clear that HDGF is a nuclear targeted protein containing a canonical bipartite nuclear localization sequence. In the developing vasculature HDGF is highly expressed in the nucleus of smooth muscle and endothelial cells. HDGF expression in smooth muscle in particular, declines after birth in larger arteries only to be re-expressed with vascular injury in cells of the highly proliferative neointima. In addition, levels of HDGF have recently been shown to be elevated in a number of cancers, suggesting a potential role in cancer development. Because of these roles, HDGF is a potential target for drug design. This review will describe current knowledge about the biochemical functioning of the protein and identify potential avenues for drug development.

Original languageEnglish (US)
Pages (from-to)367-371
Number of pages5
JournalCurrent Drug Targets
Volume4
Issue number5
DOIs
StatePublished - Jul 2003
Externally publishedYes

Fingerprint

Mitogens
Muscle
Neointima
Proteins
Drug Design
Vascular System Injuries
Endothelial cells
Nuclear Proteins
Pharmaceutical Preparations
Smooth Muscle Myocytes
Smooth Muscle
hepatoma-derived growth factor
Hepatocellular Carcinoma
Neoplasms
Endothelial Cells
Arteries
Cells
Parturition
Cell Line

Keywords

  • Growth factors
  • HDGF
  • PWWP
  • Vascular disease

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science

Cite this

Hepatoma derived growth factor is a nuclear targeted mitogen. / Everett, Allen D; Bushweleer, John.

In: Current Drug Targets, Vol. 4, No. 5, 07.2003, p. 367-371.

Research output: Contribution to journalArticle

Everett, Allen D ; Bushweleer, John. / Hepatoma derived growth factor is a nuclear targeted mitogen. In: Current Drug Targets. 2003 ; Vol. 4, No. 5. pp. 367-371.
@article{f69ec8f60a834b28aebd0f60a55a685e,
title = "Hepatoma derived growth factor is a nuclear targeted mitogen",
abstract = "Hepatoma Derived Growth Factor (HDGF) was originally identified as a secreted mitogen from the human hepatoma cell line Huh-7. Although initially thought to be a cytoplasmic protein, it became clear that HDGF is a nuclear targeted protein containing a canonical bipartite nuclear localization sequence. In the developing vasculature HDGF is highly expressed in the nucleus of smooth muscle and endothelial cells. HDGF expression in smooth muscle in particular, declines after birth in larger arteries only to be re-expressed with vascular injury in cells of the highly proliferative neointima. In addition, levels of HDGF have recently been shown to be elevated in a number of cancers, suggesting a potential role in cancer development. Because of these roles, HDGF is a potential target for drug design. This review will describe current knowledge about the biochemical functioning of the protein and identify potential avenues for drug development.",
keywords = "Growth factors, HDGF, PWWP, Vascular disease",
author = "Everett, {Allen D} and John Bushweleer",
year = "2003",
month = "7",
doi = "10.2174/1389450033490975",
language = "English (US)",
volume = "4",
pages = "367--371",
journal = "Current Drug Targets",
issn = "1389-4501",
publisher = "Bentham Science Publishers B.V.",
number = "5",

}

TY - JOUR

T1 - Hepatoma derived growth factor is a nuclear targeted mitogen

AU - Everett, Allen D

AU - Bushweleer, John

PY - 2003/7

Y1 - 2003/7

N2 - Hepatoma Derived Growth Factor (HDGF) was originally identified as a secreted mitogen from the human hepatoma cell line Huh-7. Although initially thought to be a cytoplasmic protein, it became clear that HDGF is a nuclear targeted protein containing a canonical bipartite nuclear localization sequence. In the developing vasculature HDGF is highly expressed in the nucleus of smooth muscle and endothelial cells. HDGF expression in smooth muscle in particular, declines after birth in larger arteries only to be re-expressed with vascular injury in cells of the highly proliferative neointima. In addition, levels of HDGF have recently been shown to be elevated in a number of cancers, suggesting a potential role in cancer development. Because of these roles, HDGF is a potential target for drug design. This review will describe current knowledge about the biochemical functioning of the protein and identify potential avenues for drug development.

AB - Hepatoma Derived Growth Factor (HDGF) was originally identified as a secreted mitogen from the human hepatoma cell line Huh-7. Although initially thought to be a cytoplasmic protein, it became clear that HDGF is a nuclear targeted protein containing a canonical bipartite nuclear localization sequence. In the developing vasculature HDGF is highly expressed in the nucleus of smooth muscle and endothelial cells. HDGF expression in smooth muscle in particular, declines after birth in larger arteries only to be re-expressed with vascular injury in cells of the highly proliferative neointima. In addition, levels of HDGF have recently been shown to be elevated in a number of cancers, suggesting a potential role in cancer development. Because of these roles, HDGF is a potential target for drug design. This review will describe current knowledge about the biochemical functioning of the protein and identify potential avenues for drug development.

KW - Growth factors

KW - HDGF

KW - PWWP

KW - Vascular disease

UR - http://www.scopus.com/inward/record.url?scp=0038205701&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038205701&partnerID=8YFLogxK

U2 - 10.2174/1389450033490975

DO - 10.2174/1389450033490975

M3 - Article

VL - 4

SP - 367

EP - 371

JO - Current Drug Targets

JF - Current Drug Targets

SN - 1389-4501

IS - 5

ER -