Hepatocyte plasma membrane ecto-ATPase ( pp120 HA4) is a substrate for tyrosine kinase activity of the insulin receptor

Ronald N. Margolis, Michael J. Schell, Simeon I. Taylor, Ann L. Hubbard

Research output: Contribution to journalArticlepeer-review

Abstract

pp120 HA4, a membrane protein found in hepatocyte plasma membranes and a substrate for the insulin receptor tyrosine kinase, was purified to homogeneity, subjected to partial proteolysis, and peptides were sequenced by Edman degradation. Six amino acid sequences were obtained, and they matched the deduced amino acid sequences of six regions of a hepatocyte membrane protein called ecto-ATPase.

Original languageEnglish (US)
Pages (from-to)562-566
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume166
Issue number2
DOIs
StatePublished - Jan 30 1990

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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