Hepatocyte growth factor/met gene transfer in cardiac stem cells-potential for cardiac repair

Rosalinda Madonna, Gregg Rokosh, Raffaele De Caterina, Roberto Bolli

Research output: Contribution to journalReview articlepeer-review

Abstract

The adult heart has been recently recognized as a self-renewing organ that contains a pool of committed resident cardiac stem cells (CSCs) and cardiac progenitor cells (CPCs). These adult CSCs and CPCs can be induced by cytokines and growth factors to migrate, differentiate, and proliferate in situ and potentially replace lost cardiomyocytes. Ligand-receptor systems, such as the tyrosine kinase receptor mesenchymal-epithelial transition factor (Met) and its ligand hepatocyte growth factor (HGF), are potential candidates for boosting migration, engraftment and commitment of CSCs. Here, we discuss the possible application of HGF/Met gene therapy to enhance the ability of CSCs to promote myocardial regeneration.

Original languageEnglish (US)
Pages (from-to)443-452
Number of pages10
JournalBasic Research in Cardiology
Volume105
Issue number4
DOIs
StatePublished - Jul 2010

Keywords

  • Cardiac progenitor cells
  • Cardiac repair
  • Cardiac stem cells
  • Cell-based therapy
  • Gene therapy
  • Hepatocyte growth factor

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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