Hepatocyte growth factor promotes proliferation and migration in immortalized progenitor cells

Feng Lan, Jinchong Xu, Xiaoyan Zhang, Vincent Wai Sun Wong, Xiaoxia Li, Aili Lu, Wenjing Lu, Li Shen, Lingsong Li

Research output: Contribution to journalArticlepeer-review

Abstract

Hepatocyte growth factor (HGF) and its receptor c-Met are widely expressed in the developing and adult brain. However, little is known about the role of HGF during the development of the human dopaminergic neuronal system. We have established telomerase-immortalized dopaminergic progenitor cells isolated from the fetal striatum that express markers for neural progenitor cells and tyrosine hydroxylase. We show that the cells were able to differentiate into dopaminergic neurons and release dopamine. Exogenous HGF-induced proliferation was inhibited by U0126, whereas migration was completely blocked by LY294002. Study demonstrates that HGF regulates the proliferation and migration of dopaminergic progenitor cells. Modulating dopaminergic progenitor cells in the striatum may prove to be a new approach for treating Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)765-769
Number of pages5
JournalNeuroreport
Volume19
Issue number7
DOIs
StatePublished - May 1 2008
Externally publishedYes

Keywords

  • Dopaminergic progenitor cells
  • Hepatocyte growth factor
  • Immortalization
  • Migration
  • Proliferation

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Hepatocyte growth factor promotes proliferation and migration in immortalized progenitor cells'. Together they form a unique fingerprint.

Cite this