Hepatocellular carcinoma-fibrolamellar variant: Cytopathology of an unusual case

George Kunz, Jeffrey Chung, Syed Z. Ali

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


The fibrolamellar variant of hepatocellular carcinoma (FL-HCC) is an uncommon visceral malignancy with a distinctly better prognosis. An accurate initial diagnosis, therefore, is essential for prognostic and therapeutic reasons. This case report describes the cytomorphology of an unusual case of FL-HCC in a 13-yr-old boy who was found to have a hepatic mass with prominent intraluminal growth pattern seen predominantly in the right hepatic duct. A diagnosis of FL-HCC was originally suspected on bile duct brushings obtained during endoscopic retrograde choleangiopancreaticogram (ERCP) and subsequently confirmed on fine-needle aspiration (FNA) and surgical resection of the hepatic tumor. The cytomorphologic profile of FL-HCC is distinctive in the right clinical setting, allowing an accurate preoperative identification of this malignancy on biliary brushing or FNA.

Original languageEnglish (US)
Pages (from-to)257-261
Number of pages5
JournalDiagnostic cytopathology
Issue number4
StatePublished - 2002


  • Biliary brushing
  • Cytopathology
  • Fibrolamellar variant
  • Fine-needle aspiration
  • Hepatocellular carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology


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