Hepatoblastoma and familial adenomatous polyposis

J. E. Garber, F. P. Li, J. E. Kingston, A. J. Krush, L. C. Strong, M. J. Finegold, L. Bertario, S. Bülow, A. Filippone, T. Gedde-dahl, H. J. Järvinen

Research output: Contribution to journalArticle

Abstract

Eleven children have been identified as having hepatoblastoma and a family history of adenomatous polyposis, and 14 additional instances of this association have been collected from the literature. Among the 11 survivors of hepatoblastoma in the combined series, adenomatous lesions have been sought in seven and detected in six patients at ages 7 to 25 years. Five of these patients also have congenital hypertrophy of the rential pigment epithelium, a marker for carriers of the polyposis gene. These findings strengthen the association between hepatoblastoma and familial adenomatous polyposis and have led to the establishment of the Hepatoblastoma-Adenomatous Polyposis Registry.

Original languageEnglish (US)
Pages (from-to)1626-1628
Number of pages3
JournalJournal of the National Cancer Institute
Volume80
Issue number20
DOIs
StatePublished - Dec 21 1988

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Garber, J. E., Li, F. P., Kingston, J. E., Krush, A. J., Strong, L. C., Finegold, M. J., Bertario, L., Bülow, S., Filippone, A., Gedde-dahl, T., & Järvinen, H. J. (1988). Hepatoblastoma and familial adenomatous polyposis. Journal of the National Cancer Institute, 80(20), 1626-1628. https://doi.org/10.1093/jnci/80.20.1626