Hepato and reno protective action of calendula officinalis L. Flower extract

Preethi Korangath, Ramadasan Kuttan

Research output: Contribution to journalArticle

Abstract

Flower extract of C. officinalis L. was evaluated for its protective effect against CCl4 induced acute hepatotoxicity and cisplatin induced nephrotoxicity. The activities of serum marker enzymes of liver injury like glutamate pyruvate transaminase (SGPT), glutamate oxaloacetate transaminase (SGOT) and alkaline phosphatase (ALP) which were increased by CCl4 injection was found to be significantly reduced by the pretreatment of the flower extract at 100 and 250 mg/kg body weight. The lipid peroxidation in liver, the marker of membrane damage and the total bilirubin content in serum were also found to be at significantly low level in the extract pretreated group, indicating its protective role. The kidney function markers like urea and creatinine were significantly increased in cisplatin treated animals. However, their levels were found to be lowered in the extract pretreated groups (100 and 250 mg/kg body weight). Moreover, cisplatin induced myelosuppression was ameliorated by the extract pretreatment. Treatment with the extract produced enhancement of antioxidant enzymes superoxide dismutase and catalase and glutathione. Results suggest a protective role of the flower extract of C. officinalis against CCl4 induced acute hepatotoxicity and cisplatin induced nephrotoxicity. Extract has been found to contain several carotenoids of which lutein, zeaxanthin and lycopene predominates. Possible mechanism of action of the flower extract may be due to its antioxidant activity and reduction of oxygen radicals.

Original languageEnglish (US)
Pages (from-to)163-168
Number of pages6
JournalIndian Journal of Experimental Biology
Volume47
Issue number3
StatePublished - Mar 2009
Externally publishedYes

Fingerprint

Calendula
Cisplatin
Transaminases
Glutamic Acid
Antioxidants
Body Weight
Oxaloacetic Acid
Lutein
Liver
Enzymes
Carotenoids
Alanine Transaminase
Pyruvic Acid
Bilirubin
Catalase
Lipid Peroxidation
Superoxide Dismutase
Glutathione
Alkaline Phosphatase
Urea

Keywords

  • Antioxidant
  • Calendula officinalis
  • CCl
  • Cisplatin
  • Hepatoprotection
  • Nephroprotection

ASJC Scopus subject areas

  • Biotechnology
  • Cell Biology
  • Molecular Biology

Cite this

Hepato and reno protective action of calendula officinalis L. Flower extract. / Korangath, Preethi; Kuttan, Ramadasan.

In: Indian Journal of Experimental Biology, Vol. 47, No. 3, 03.2009, p. 163-168.

Research output: Contribution to journalArticle

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