Hepatitis C virus infection and its rheumatologic implications

Zeynel A. Sayiner, Uzma Haque, Mohammad U. Malik, Ahmet Gurakar

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Extrahepatic manifestations are frequently encountered among patients with chronic hepatitis C virus (HCV) infection. Many of these manifestations are autoimmune disorders, with added mortality and morbidity due to involvement of multiple organ systems. Symptoms of HCV infection and rheumatic diseases may be similar and include arthralgia, myalgia, arthritis, and vasculitis. Also, serologic abnormalities may be found in both cases. Some treatment modalities for HCV infection, including interferon therapy, may aggravate the symptoms of rheumatic diseases, thus confounding clinical presentation. It is imperative to distinguish whether symptoms such as arthralgia, myalgia, and arthritis occur in patients with HCV infection due to primary chronic HCV infection or to a newly developed rheumatologic disease process.

Original languageEnglish (US)
Pages (from-to)287-293
Number of pages7
JournalGastroenterology and Hepatology
Issue number5
StatePublished - May 2014


  • Autoimmune disease
  • Hepatitis C virus
  • Rheumatologic implication

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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