Hepatitis C virus evasion of adaptive immune responses: A model for viral persistence

Kelly P. Burke; Andrea L. Cox

doi:10.1007/s12026-009-8152-3

Hepatitis C virus evasion of adaptive immune responses: A model for viral persistence

Kelly P. Burke, Andrea L. Cox

School of Medicine

Research output: Contribution to journal › Review article › peer-review

50 Scopus citations

Abstract

Hepatitis C virus (HCV) infects over 170 million people worldwide and is a leading cause of cirrhosis and hepatocellular carcinoma. Approximately 80% of those acutely infected clear the infection, whereas the remaining 20% progress to chronic infection. Hepatitis C thus provides a model in which successful and unsuccessful responses can be compared to better understand the human response to viral infection. Our laboratory studies the strategies by which HCV evades the adaptive immune response. This review describes the impact of viral mutation on T cell recognition, the role of cell surface inhibitory receptors in recognition of HCV, and the development of antibodies that neutralize HCV infection. Understanding what constitutes an effective immune response in the control of HCV may enable the development of prophylactic and therapeutic vaccines for HCV and other chronic viral infections.

Original language	English (US)
Pages (from-to)	216-227
Number of pages	12
Journal	Immunologic Research
Volume	47
Issue number	1-3
DOIs	https://doi.org/10.1007/s12026-009-8152-3
State	Published - Jul 2010

Keywords

CD8 T cell
Epitope variant
Hepatitis C virus
Viral escape
Viral immunity

ASJC Scopus subject areas

Immunology

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10.1007/s12026-009-8152-3

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title = "Hepatitis C virus evasion of adaptive immune responses: A model for viral persistence",

abstract = "Hepatitis C virus (HCV) infects over 170 million people worldwide and is a leading cause of cirrhosis and hepatocellular carcinoma. Approximately 80% of those acutely infected clear the infection, whereas the remaining 20% progress to chronic infection. Hepatitis C thus provides a model in which successful and unsuccessful responses can be compared to better understand the human response to viral infection. Our laboratory studies the strategies by which HCV evades the adaptive immune response. This review describes the impact of viral mutation on T cell recognition, the role of cell surface inhibitory receptors in recognition of HCV, and the development of antibodies that neutralize HCV infection. Understanding what constitutes an effective immune response in the control of HCV may enable the development of prophylactic and therapeutic vaccines for HCV and other chronic viral infections.",

keywords = "CD8 T cell, Epitope variant, Hepatitis C virus, Viral escape, Viral immunity",

author = "Burke, {Kelly P.} and Cox, {Andrea L.}",

note = "Funding Information: Acknowledgments This work was supported by NIH grants U19AI040035, R01DA024565, R01AI077757 and 5T32GM007309, as well as grants from The Damon Runyon Cancer Research Foundation and The Dana Foundation.",

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AU - Cox, Andrea L.

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PY - 2010/7

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N2 - Hepatitis C virus (HCV) infects over 170 million people worldwide and is a leading cause of cirrhosis and hepatocellular carcinoma. Approximately 80% of those acutely infected clear the infection, whereas the remaining 20% progress to chronic infection. Hepatitis C thus provides a model in which successful and unsuccessful responses can be compared to better understand the human response to viral infection. Our laboratory studies the strategies by which HCV evades the adaptive immune response. This review describes the impact of viral mutation on T cell recognition, the role of cell surface inhibitory receptors in recognition of HCV, and the development of antibodies that neutralize HCV infection. Understanding what constitutes an effective immune response in the control of HCV may enable the development of prophylactic and therapeutic vaccines for HCV and other chronic viral infections.

AB - Hepatitis C virus (HCV) infects over 170 million people worldwide and is a leading cause of cirrhosis and hepatocellular carcinoma. Approximately 80% of those acutely infected clear the infection, whereas the remaining 20% progress to chronic infection. Hepatitis C thus provides a model in which successful and unsuccessful responses can be compared to better understand the human response to viral infection. Our laboratory studies the strategies by which HCV evades the adaptive immune response. This review describes the impact of viral mutation on T cell recognition, the role of cell surface inhibitory receptors in recognition of HCV, and the development of antibodies that neutralize HCV infection. Understanding what constitutes an effective immune response in the control of HCV may enable the development of prophylactic and therapeutic vaccines for HCV and other chronic viral infections.

KW - CD8 T cell

KW - Epitope variant

KW - Hepatitis C virus

KW - Viral escape

KW - Viral immunity

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Hepatitis C virus evasion of adaptive immune responses: A model for viral persistence

Abstract

Keywords

ASJC Scopus subject areas

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