Hepatitis C Viremia Is Associated with Cytomegalovirus IgG Antibody Levels in HIV-Infected Women

Mark H. Kuniholm, Christina M. Parrinello, Kathryn Anastos, Michael Augenbraun, Michael Plankey, Marek Nowicki, Marion Peters, Elizabeth Golub, Nell Lurain, Alan L. Landay, Howard D. Strickler, Robert C. Kaplan

Research output: Contribution to journalArticle

Abstract

Background: Individuals with HIV infection exhibit high cytomegalovirus (CMV) IgG levels, but there are few data regarding the association of hepatitis C virus (HCV) with the immune response against CMV. Methods: Associations of HCV with CMV seropositivity and CMV IgG levels were studied in 635 HIV-infected women, 187 of whom were HCV-seropositive, with adjustment in multivariable models for age, race/ethnicity, and HIV disease characteristics. Eighty one percent of the women reported receipt of highly active antiretroviral therapy (HAART) prior to or at CMV testing. Results: In adjusted models women with chronic HCV had higher CMV IgG levels than those without HCV RNA (β = 2.86, 95% CI:0.89 - 4.83; P = 0.004). The association of HCV RNA with CMV IgG differed by age (Pinteraction = 0.0007), with a strong association observed among women in the low and middle age tertiles (≤45.3 years of age; β = 6.21, 95% CI:3.30 - 9.11, P

Original languageEnglish (US)
Article numbere61973
JournalPLoS One
Volume8
Issue number4
DOIs
StatePublished - Apr 17 2013

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hepatitis C
Cytomegalovirus
Viremia
viremia
Hepatitis C
Hepatitis C virus
Viruses
Hepacivirus
Immunoglobulin G
HIV
antibodies
Antibodies
RNA
chronic hepatitis C
Highly Active Antiretroviral Therapy
HIV infections
Chronic Hepatitis C
nationalities and ethnic groups
seroprevalence
HIV Infections

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Kuniholm, M. H., Parrinello, C. M., Anastos, K., Augenbraun, M., Plankey, M., Nowicki, M., ... Kaplan, R. C. (2013). Hepatitis C Viremia Is Associated with Cytomegalovirus IgG Antibody Levels in HIV-Infected Women. PLoS One, 8(4), [e61973]. https://doi.org/10.1371/journal.pone.0061973

Hepatitis C Viremia Is Associated with Cytomegalovirus IgG Antibody Levels in HIV-Infected Women. / Kuniholm, Mark H.; Parrinello, Christina M.; Anastos, Kathryn; Augenbraun, Michael; Plankey, Michael; Nowicki, Marek; Peters, Marion; Golub, Elizabeth; Lurain, Nell; Landay, Alan L.; Strickler, Howard D.; Kaplan, Robert C.

In: PLoS One, Vol. 8, No. 4, e61973, 17.04.2013.

Research output: Contribution to journalArticle

Kuniholm, MH, Parrinello, CM, Anastos, K, Augenbraun, M, Plankey, M, Nowicki, M, Peters, M, Golub, E, Lurain, N, Landay, AL, Strickler, HD & Kaplan, RC 2013, 'Hepatitis C Viremia Is Associated with Cytomegalovirus IgG Antibody Levels in HIV-Infected Women', PLoS One, vol. 8, no. 4, e61973. https://doi.org/10.1371/journal.pone.0061973
Kuniholm MH, Parrinello CM, Anastos K, Augenbraun M, Plankey M, Nowicki M et al. Hepatitis C Viremia Is Associated with Cytomegalovirus IgG Antibody Levels in HIV-Infected Women. PLoS One. 2013 Apr 17;8(4). e61973. https://doi.org/10.1371/journal.pone.0061973
Kuniholm, Mark H. ; Parrinello, Christina M. ; Anastos, Kathryn ; Augenbraun, Michael ; Plankey, Michael ; Nowicki, Marek ; Peters, Marion ; Golub, Elizabeth ; Lurain, Nell ; Landay, Alan L. ; Strickler, Howard D. ; Kaplan, Robert C. / Hepatitis C Viremia Is Associated with Cytomegalovirus IgG Antibody Levels in HIV-Infected Women. In: PLoS One. 2013 ; Vol. 8, No. 4.
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