Hepatitis C antibody in a non-hemophiliac cohort infected with the human immunodeficiency virus

D. R. Lucey, Craig Hendrix, C. Andrzejewski, D. McGlasson, W. W. Ward, G. P. Melcher, R. A. Zajac, R. N. Boswell

Research output: Contribution to journalArticle

Abstract

Development of a serologic test which detects antibody to hepatitis C virus (anti-HCV) allowed us to compare the seroprevalence of hepatitis C and hepatitis B in 493 persons infected with the human immunodeficiency virus (HIV). These persons, none of whom are hemophiliacs, are part of the US Air Force HIV Natural History Study. We found that Hepatitis B core antibody (anti-HBc) was far more prevalent (59%) than anti-HCV (8%). Anti-HBc prevalence was not different between those with and those without anti-HCV, being present in the majority of persons in both groups. In addition, we compared anti-HCV+ and anti-HCV negative persons in terms of syphilis serologies (Reactive Plasma Reagent [RPR] and Fluorescent Treponemal Antibody Absorption [FTA-ABS]), hepatic transaminase levels, and racial composition. In this cohort, we found that anti-HCV+ persons are significantly more likely to have a positive RPR but not FTA-ABS, increased hepatic transaminase levels, and to be Black rather than Caucasian.

Original languageEnglish (US)
Pages (from-to)295-301
Number of pages7
JournalViral Immunology
Volume3
Issue number4
StatePublished - 1990
Externally publishedYes

Fingerprint

Hepatitis C Antibodies
HIV
Transaminases
Antibodies
Hepatitis B Antibodies
Liver
Seroepidemiologic Studies
Serologic Tests
Serology
Syphilis
Hepatitis C
Natural History
Hepatitis B
Hepacivirus
Air

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Lucey, D. R., Hendrix, C., Andrzejewski, C., McGlasson, D., Ward, W. W., Melcher, G. P., ... Boswell, R. N. (1990). Hepatitis C antibody in a non-hemophiliac cohort infected with the human immunodeficiency virus. Viral Immunology, 3(4), 295-301.

Hepatitis C antibody in a non-hemophiliac cohort infected with the human immunodeficiency virus. / Lucey, D. R.; Hendrix, Craig; Andrzejewski, C.; McGlasson, D.; Ward, W. W.; Melcher, G. P.; Zajac, R. A.; Boswell, R. N.

In: Viral Immunology, Vol. 3, No. 4, 1990, p. 295-301.

Research output: Contribution to journalArticle

Lucey, DR, Hendrix, C, Andrzejewski, C, McGlasson, D, Ward, WW, Melcher, GP, Zajac, RA & Boswell, RN 1990, 'Hepatitis C antibody in a non-hemophiliac cohort infected with the human immunodeficiency virus', Viral Immunology, vol. 3, no. 4, pp. 295-301.
Lucey DR, Hendrix C, Andrzejewski C, McGlasson D, Ward WW, Melcher GP et al. Hepatitis C antibody in a non-hemophiliac cohort infected with the human immunodeficiency virus. Viral Immunology. 1990;3(4):295-301.
Lucey, D. R. ; Hendrix, Craig ; Andrzejewski, C. ; McGlasson, D. ; Ward, W. W. ; Melcher, G. P. ; Zajac, R. A. ; Boswell, R. N. / Hepatitis C antibody in a non-hemophiliac cohort infected with the human immunodeficiency virus. In: Viral Immunology. 1990 ; Vol. 3, No. 4. pp. 295-301.
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