Hepatitis C antibody in a non-hemophiliac cohort infected with the human immunodeficiency virus

D. R. Lucey, C. W. Hendrix, C. Andrzejewski, D. McGlasson, W. W. Ward, G. P. Melcher, R. A. Zajac, R. N. Boswell

Research output: Contribution to journalArticle

Abstract

Development of a serologic test which detects antibody to hepatitis C virus (anti-HCV) allowed us to compare the seroprevalence of hepatitis C and hepatitis B in 493 persons infected with the human immunodeficiency virus (HIV). These persons, none of whom are hemophiliacs, are part of the US Air Force HIV Natural History Study. We found that Hepatitis B core antibody (anti-HBc) was far more prevalent (59%) than anti-HCV (8%). Anti-HBc prevalence was not different between those with and those without anti-HCV, being present in the majority of persons in both groups. In addition, we compared anti-HCV+ and anti-HCV negative persons in terms of syphilis serologies (Reactive Plasma Reagent [RPR] and Fluorescent Treponemal Antibody Absorption [FTA-ABS]), hepatic transaminase levels, and racial composition. In this cohort, we found that anti-HCV+ persons are significantly more likely to have a positive RPR but not FTA-ABS, increased hepatic transaminase levels, and to be Black rather than Caucasian.

Original languageEnglish (US)
Pages (from-to)295-301
Number of pages7
JournalViral Immunology
Volume3
Issue number4
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology
  • Molecular Medicine
  • Virology

Cite this

Lucey, D. R., Hendrix, C. W., Andrzejewski, C., McGlasson, D., Ward, W. W., Melcher, G. P., Zajac, R. A., & Boswell, R. N. (1990). Hepatitis C antibody in a non-hemophiliac cohort infected with the human immunodeficiency virus. Viral Immunology, 3(4), 295-301. https://doi.org/10.1089/vim.1990.3.295