Hepatitis B and C

Wikrom Karnsakul; Kathleen B. Schwarz

doi:10.1016/j.pcl.2017.01.007

Hepatitis B and C

Wikrom Karnsakul, Kathleen B. Schwarz

School of Medicine

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

Chronic viral hepatitis is a global health threat and financial burden. Hepatitis B and C viruses (HBV and HCV) are the most common causes of chronic viral hepatitis in the United States. Most cases are asymptomatic before adulthood. Research has resulted in effective therapy for HCV and the promise of effective therapies for HBV. For HCV, therapy is pegylated interferon and ribavirin. Clinical trials with effective direct-acting antiviral agents are underway in pediatrics. For HBV, approved agents are alpha-interferon, lamivudine, adefovir, tenofovir, and entecavir. However, treatment seldom results in functional cure and more effective therapies are urgently needed.

Original language	English (US)
Pages (from-to)	641-658
Number of pages	18
Journal	Pediatric clinics of North America
Volume	64
Issue number	3
DOIs	https://doi.org/10.1016/j.pcl.2017.01.007
State	Published - Jun 2017

Keywords

Direct-acting antiviral agents
Hepatitis B
Hepatitis C
Pegylated interferon
Spontaneous viral clearance
Sustained virologic response

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1016/j.pcl.2017.01.007

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title = "Hepatitis B and C",

abstract = "Chronic viral hepatitis is a global health threat and financial burden. Hepatitis B and C viruses (HBV and HCV) are the most common causes of chronic viral hepatitis in the United States. Most cases are asymptomatic before adulthood. Research has resulted in effective therapy for HCV and the promise of effective therapies for HBV. For HCV, therapy is pegylated interferon and ribavirin. Clinical trials with effective direct-acting antiviral agents are underway in pediatrics. For HBV, approved agents are alpha-interferon, lamivudine, adefovir, tenofovir, and entecavir. However, treatment seldom results in functional cure and more effective therapies are urgently needed.",

keywords = "Direct-acting antiviral agents, Hepatitis B, Hepatitis C, Pegylated interferon, Spontaneous viral clearance, Sustained virologic response",

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AU - Karnsakul, Wikrom

AU - Schwarz, Kathleen B.

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N2 - Chronic viral hepatitis is a global health threat and financial burden. Hepatitis B and C viruses (HBV and HCV) are the most common causes of chronic viral hepatitis in the United States. Most cases are asymptomatic before adulthood. Research has resulted in effective therapy for HCV and the promise of effective therapies for HBV. For HCV, therapy is pegylated interferon and ribavirin. Clinical trials with effective direct-acting antiviral agents are underway in pediatrics. For HBV, approved agents are alpha-interferon, lamivudine, adefovir, tenofovir, and entecavir. However, treatment seldom results in functional cure and more effective therapies are urgently needed.

AB - Chronic viral hepatitis is a global health threat and financial burden. Hepatitis B and C viruses (HBV and HCV) are the most common causes of chronic viral hepatitis in the United States. Most cases are asymptomatic before adulthood. Research has resulted in effective therapy for HCV and the promise of effective therapies for HBV. For HCV, therapy is pegylated interferon and ribavirin. Clinical trials with effective direct-acting antiviral agents are underway in pediatrics. For HBV, approved agents are alpha-interferon, lamivudine, adefovir, tenofovir, and entecavir. However, treatment seldom results in functional cure and more effective therapies are urgently needed.

KW - Direct-acting antiviral agents

KW - Hepatitis B

KW - Hepatitis C

KW - Pegylated interferon

KW - Spontaneous viral clearance

KW - Sustained virologic response

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Hepatitis B and C

Abstract

Keywords

ASJC Scopus subject areas

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