Hepatitis B

Kenneth W. Lin, Jeffrey T. Kirchner

Research output: Contribution to journalArticle

Abstract

Hepatitis B causes significant morbidity and mortality worldwide. More than 400 million persons, including 1.25 million Americans, have chronic hepatitis B. In the United States, chronic hepatitis B virus infection is responsible for about 5,000 annual deaths from cirrhosis and hepatocellular carcinoma. Hepatitis B virus is found in body fluids and secretions; in developed countries, the virus is most commonly transmitted sexually or via intravenous drug use. Occupational exposure and perinatal transmission do occur but are rare in the United States. Effective vaccines for hepatitis B virus have been available since 1982; infant and childhood vaccination programs introduced in the 1990s have resulted in a marked decrease in new infections. Risk factors for progression to chronic infection include age at the time of infection and impaired immunity. From 15 to 30 percent of patients with acute hepatitis B infection progress to chronic infection. Medical therapies for chronic hepatitis B include interferon alfa-2b, lamivudine, and the nucleotide analog adefovir dipivoxil. Copyright 2004

Original languageEnglish (US)
Pages (from-to)75-82+86
JournalAmerican Family Physician
Volume69
Issue number1
StatePublished - Jan 1 2004
Externally publishedYes

Fingerprint

Hepatitis B
Chronic Hepatitis B
Hepatitis B virus
Infection
interferon alfa-2b
Fluids and Secretions
Lamivudine
Body Fluids
Virus Diseases
Occupational Exposure
Developed Countries
Hepatocellular Carcinoma
Immunity
Vaccination
Fibrosis
Vaccines
Nucleotides
Viruses
Morbidity
Mortality

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lin, K. W., & Kirchner, J. T. (2004). Hepatitis B. American Family Physician, 69(1), 75-82+86.

Hepatitis B. / Lin, Kenneth W.; Kirchner, Jeffrey T.

In: American Family Physician, Vol. 69, No. 1, 01.01.2004, p. 75-82+86.

Research output: Contribution to journalArticle

Lin, KW & Kirchner, JT 2004, 'Hepatitis B', American Family Physician, vol. 69, no. 1, pp. 75-82+86.
Lin KW, Kirchner JT. Hepatitis B. American Family Physician. 2004 Jan 1;69(1):75-82+86.
Lin, Kenneth W. ; Kirchner, Jeffrey T. / Hepatitis B. In: American Family Physician. 2004 ; Vol. 69, No. 1. pp. 75-82+86.
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