Hepatitis A outbreaks

The effect of a mass vaccination programme

Nuria Torner, S. Broner, A. Martinez, P. Godoy, J. Batalla, A. Dominguez, M. Alsedà, J. Àlvarez, C. Arias, A. Artigues, P. J. Balañà, I. Barrabeig, N. Camps, G. Carmona, M. Carol, M. Company, G. Ferrús, N. Fullia, S. Minguell, I. Parrón & 7 others A. Rovira, L. Ruiz, M. R. Sala, R. Torra, J. Torres, J. Caylà, C. Tortajada

Research output: Contribution to journalArticle

Abstract

A Hepatitis A vaccination programme of people belonging to risk groups begun in Catalonia in 1995 and a universal vaccination programme of pre-adolescents 12 years of age with the hepatitis A + B vaccine was added in 1998. The aim of the study was to investigate the characteristics of hepatitis A outbreaks occurring in Catalonia between 1991 and 2007 to determine the associated risk factors and optimize the use of vaccination. Incidence rates of outbreaks, cases and hospitalizations associated with outbreaks and the rate ratios (RR) of person-to-person transmission outbreaks between the periods before and after mass vaccination and their 95% confidence intervals (CI) were calculated. A rate of 2.45 outbreaks per million persons per year was found. The rate of cases affected in these outbreaks was 1.28 per 105 persons per year and the rate of hospitalizations was 0.45 per million persons per year. In person-to-person outbreaks, the highest incidence rate (5.26 and 6.33 per million persons per year) of outbreaks according to the age of the index case was in the 5 to 14 year age group in both periods (RR:0.83; 95% CI:0.48-1.43). A significant increase was observed in the 25 to 44 year age group (RR: 0.35; 95% CI 0.14-0.77). Hepatitis A vaccination has made an important impact on burden and characteristics of outbreaks and could provide greater benefits to the community if the vaccine was administrated to children during their first years of life.

Original languageEnglish (US)
JournalJournal of Viral Hepatitis
Volume18
Issue number4
DOIs
StatePublished - Apr 2011
Externally publishedYes

Fingerprint

Mass Vaccination
Hepatitis A
Disease Outbreaks
Vaccination
Confidence Intervals
Hospitalization
Age Groups
Incidence
Vaccines

Keywords

  • Age
  • Hepatitis A
  • Mass vaccination
  • Outbreak

ASJC Scopus subject areas

  • Hepatology
  • Infectious Diseases
  • Virology

Cite this

Torner, N., Broner, S., Martinez, A., Godoy, P., Batalla, J., Dominguez, A., ... Tortajada, C. (2011). Hepatitis A outbreaks: The effect of a mass vaccination programme. Journal of Viral Hepatitis, 18(4). https://doi.org/10.1111/j.1365-2893.2010.01395.x

Hepatitis A outbreaks : The effect of a mass vaccination programme. / Torner, Nuria; Broner, S.; Martinez, A.; Godoy, P.; Batalla, J.; Dominguez, A.; Alsedà, M.; Àlvarez, J.; Arias, C.; Artigues, A.; Balañà, P. J.; Barrabeig, I.; Camps, N.; Carmona, G.; Carol, M.; Company, M.; Ferrús, G.; Fullia, N.; Minguell, S.; Parrón, I.; Rovira, A.; Ruiz, L.; Sala, M. R.; Torra, R.; Torres, J.; Caylà, J.; Tortajada, C.

In: Journal of Viral Hepatitis, Vol. 18, No. 4, 04.2011.

Research output: Contribution to journalArticle

Torner, N, Broner, S, Martinez, A, Godoy, P, Batalla, J, Dominguez, A, Alsedà, M, Àlvarez, J, Arias, C, Artigues, A, Balañà, PJ, Barrabeig, I, Camps, N, Carmona, G, Carol, M, Company, M, Ferrús, G, Fullia, N, Minguell, S, Parrón, I, Rovira, A, Ruiz, L, Sala, MR, Torra, R, Torres, J, Caylà, J & Tortajada, C 2011, 'Hepatitis A outbreaks: The effect of a mass vaccination programme', Journal of Viral Hepatitis, vol. 18, no. 4. https://doi.org/10.1111/j.1365-2893.2010.01395.x
Torner, Nuria ; Broner, S. ; Martinez, A. ; Godoy, P. ; Batalla, J. ; Dominguez, A. ; Alsedà, M. ; Àlvarez, J. ; Arias, C. ; Artigues, A. ; Balañà, P. J. ; Barrabeig, I. ; Camps, N. ; Carmona, G. ; Carol, M. ; Company, M. ; Ferrús, G. ; Fullia, N. ; Minguell, S. ; Parrón, I. ; Rovira, A. ; Ruiz, L. ; Sala, M. R. ; Torra, R. ; Torres, J. ; Caylà, J. ; Tortajada, C. / Hepatitis A outbreaks : The effect of a mass vaccination programme. In: Journal of Viral Hepatitis. 2011 ; Vol. 18, No. 4.
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AU - Dominguez, A.

AU - Alsedà, M.

AU - Àlvarez, J.

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AU - Fullia, N.

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AU - Parrón, I.

AU - Rovira, A.

AU - Ruiz, L.

AU - Sala, M. R.

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