Hepatic steatosis, obesity, and the metabolic syndrome are independently and additively associated with increased systemic inflammation

Chiadi E. Ndumele, Khurram Nasir, Raquel D. Conceiçao, Jose A.M. Carvalho, Roger S. Blumenthal, Raul D. Santos

Research output: Contribution to journalArticlepeer-review

Abstract

Objective-: The goal of this study was to assess the independent and collective associations of hepatic steatosis, obesity, and the metabolic syndrome with elevated high-sensitivity C-reactive protein (hs-CRP) levels. Methods and results-: We evaluated 2388 individuals without clinical cardiovascular disease between December 2004 and December 2006. Hepatic steatosis was diagnosed by ultrasound, and the metabolic syndrome was defined using National Heart, Lung, and Blood Institute criteria. The cut point of 3 mg/L was used to define high hs-CRP. Multivariate logistic regression was used to assess the independent and collective associations of hepatic steatosis, obesity, and the metabolic syndrome with high hs-CRP. Steatosis was detected in 32% of participants, 23% met criteria for metabolic syndrome, and 17% were obese. After multivariate regression, hepatic steatosis (odds ratio [OR] 2.07; 95% CI 1.68 to 2.56), obesity (OR 3.00; 95% CI 2.39 to 3.80), and the metabolic syndrome (2.39; 95% CI 1.88 to 3.04) were all independently associated with high hs-CRP. Combinations of these factors were associated with an additive increase in the odds of high hs-CRP, with individuals with 1, 2, and 3 factors having ORs for high hs-CRP of 1.92 (1.49 to 2.48), 3.38 (2.50 to 4.57), and 4.53 (3.23 to 6.35), respectively. Conclusion-: Hepatic steatosis, obesity, and the metabolic syndrome are independently and additively associated with increased odds of high hs-CRP levels.

Original languageEnglish (US)
Pages (from-to)1927-1932
Number of pages6
JournalArteriosclerosis, thrombosis, and vascular biology
Volume31
Issue number8
DOIs
StatePublished - Aug 2011

Keywords

  • CRP
  • cytokines
  • hepatic steatosis
  • metabolic syndrome
  • obesity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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