Hepatic pathology in human monocytic ehrlichiosis: Ehrlichia chaffeensis infection

Ann E.Smith Sehdev, J. Stephen Dumler

Research output: Contribution to journalArticlepeer-review

Abstract

Ehrlichia chaffeensis causes human monocytic ehrlichiosis (HME) that usually includes fever, myalgias, and pancytopenia and, in 80% to 90% of patients, elevations in serum transaminase levels. Thus, the pathology of liver injury was studied in liver tissues from 7 patients with laboratory-confirmed HME. H&E and immunohistochemical stains for E chaffeensis and leukocyte markers were examined. Scattered lobular lymphohistiocytic foci and diffuse lymphohistiocytic infiltration and Kupffer cell hyperplasia with increased phagocytosis frequently were present. Various degrees of liver cell injury and death were observed. Cholestasis was evident in 6 cases, sometimes with bile duct epithelial injury. Rare to abundant E chaffeensis-infected mononuclear cells infiltrating lobules or portal regions or in Kupffer cells were observed in 5 patients. The inflammation was out of proportion to the infection in 6 cases. In the absence of infected hepatocytes or biliary epithelial cells, these findings suggest that host inflammatory or immune responses contribute to the liver injury seen in HME.

Original languageEnglish (US)
Pages (from-to)859-865
Number of pages7
JournalAmerican journal of clinical pathology
Volume119
Issue number6
DOIs
StatePublished - Jun 1 2003

Keywords

  • Bile duct injury
  • Ehrlichia chaffeensis
  • Ehrlichiosis
  • Hematophagocytosis
  • Hepatopathology
  • Immunohistochemistry
  • Lobular hepatitis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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