Hepatic morphology in cardiac dysfunction. A clinicopathologic study of 1000 subjects at autopsy

J. M. Arcidi, G. W. Moore, G. M. Hutchins

    Research output: Contribution to journalArticle

    Abstract

    Chronic passive congestion (CPC) and centrilobular necrosis (CLN) are well recognized pathologic changes, but their exact relationship to different forms of cardiac dysfunction is uncertain. The authors reviewed clinical data and hepatic, renal, and adrenal morphology related to cardiac dysfunction in 1000 autopsy subjects at The Johns Hopkins Hospital whose hearts had been studied after postmortem arteriography and fixation in distention. Fourteen pathologic variables, including body and organ size, and microscopic changes graded on a semiquantitative scale, and 18 clinical variables including congestive heart failure, shock, and cardiovascular disease, were analyzed statistically. Distinct patterns of cardiac dysfunction emerged for the two spectra of hepatic morphologic change. Among patients with variable CPC, but slight or absent CLN, the amount of CPC was predicted in a multivariate analysis by severity of right-sided congestive heart failure. CPC severity correlated with cardiac weight and chamber enlargement (P <0.001). Among patients with variable CLN, but slight or absent CPC, CLN was predicted by profound hypotension and by renal failure. In addition, CLN, but not CPC, was significantly correlated with renal acute tubular necrosis (P

    Original languageEnglish (US)
    Pages (from-to)159-166
    Number of pages8
    JournalAmerican Journal of Pathology
    Volume104
    Issue number2
    StatePublished - 1981

    Fingerprint

    Autopsy
    Necrosis
    Liver
    Heart Failure
    Kidney
    Organ Size
    Body Size
    Hypotension
    Renal Insufficiency
    Shock
    Angiography
    Cardiovascular Diseases
    Multivariate Analysis
    Weights and Measures

    ASJC Scopus subject areas

    • Pathology and Forensic Medicine

    Cite this

    Hepatic morphology in cardiac dysfunction. A clinicopathologic study of 1000 subjects at autopsy. / Arcidi, J. M.; Moore, G. W.; Hutchins, G. M.

    In: American Journal of Pathology, Vol. 104, No. 2, 1981, p. 159-166.

    Research output: Contribution to journalArticle

    Arcidi, J. M. ; Moore, G. W. ; Hutchins, G. M. / Hepatic morphology in cardiac dysfunction. A clinicopathologic study of 1000 subjects at autopsy. In: American Journal of Pathology. 1981 ; Vol. 104, No. 2. pp. 159-166.
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