Hepatic hemosiderosis in non-human primates: Quantification of liver iron using different field strengths

Jeff W.M. Bulte, Georgina F. Miller, Josef Vymazal, Rodney A. Brooks, Joseph A. Frank

Research output: Contribution to journalArticle

Abstract

Using a non-human primate model of idiopathic hemochromatosis, hemosiderin-induced T2 shortening of the liver was assessed at nine different field strengths over a range of 0.05 to 1.5 Tesla. The 1/T2 values increased linearly with field strength, with all specimens having approximately the same zero-field intercept. The slope of the field increase, termed 'field-dependent T2 proton relaxation enhancement (PRE)', appeared to be proportional to the chemically determined tissue iron content, viz. 10.8 s-1T-1 (mg Fe/g wet tissue)-1. The correlation between iron content and field-dependent T2 PRE (r = 0.94) was better than the correlation between iron content and 1/T2 values obtained at single field strengths. For livers containing ≤ 2 mg Fe/g wet weight, biexponential T2 relaxation behavior emerged at higher field strengths, with the short T2 component (intracellular water) exhibiting a linear dependence of 1/T2 on field, while T2 of the long component (extracellular/sinusoidal water) was nearly field- independent. After maceration of the specimens, all T2 relaxation curves became monoexponential, including those for high iron content at high field strengths. The present data suggest that the use of double-field MR imaging to assess the field-dependent T2 PRE has potential for specific quantification of (liver) tissue iron stores.

Original languageEnglish (US)
Pages (from-to)530-536
Number of pages7
JournalMagnetic resonance in medicine
Volume37
Issue number4
DOIs
StatePublished - Apr 1 1997

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Keywords

  • hemosiderin
  • iron quantification
  • liver
  • marmoset
  • relaxometry

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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