Hepatic artery model for evaluating the distribution of intraarterial chemotherapy infusion

Nonpulsed versus pulsed infusions

A. H. Matsumoto, K. H. Barth, R. J. Lutz, D. L. Miller

Research output: Contribution to journalArticle

Abstract

The effect of a commercially available pulsatile slow-infusion system on the degree of infusate mixing and distribution was assessed in a life-size glass model of the hepatic arterial system. The authors determined, both visually and quantitatively, the mixing homogeneity of a low-flow infusion (1.4 mL/min) of red dye through a side-hole catheter (2.5 F outer diameter) into pulsatile flow (300 mL/min) of a fluid with the same viscosity as blood. When comparing nonpulsed versus pulsed infusion techniques, the authors found that the pulsatile infusion system did not significantly improve the inhomogeneity of dye distribution in the 16 hepatic arterial branches. The results of this in vitro study suggest that a pulsatile infusion system that uses low pulse velocities without regard for cardiac cycle is less than optimal and does not significantly improve drug mixing at the standard slow infusion rates. Moreover, as potential new intraarterial delivery systems are developed to improve drug mixing, in vitro models may be the most useful means of initially evaluating their efficacy.

Original languageEnglish (US)
Pages (from-to)1077-1080
Number of pages4
JournalRadiology
Volume170
Issue number3 II
StatePublished - 1989
Externally publishedYes

Fingerprint

Intra Arterial Infusions
Hepatic Artery
Coloring Agents
Drug Therapy
Pulsatile Flow
Blood Viscosity
Liver
Pharmaceutical Preparations
Glass
Pulse
Catheters
In Vitro Techniques

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Matsumoto, A. H., Barth, K. H., Lutz, R. J., & Miller, D. L. (1989). Hepatic artery model for evaluating the distribution of intraarterial chemotherapy infusion: Nonpulsed versus pulsed infusions. Radiology, 170(3 II), 1077-1080.

Hepatic artery model for evaluating the distribution of intraarterial chemotherapy infusion : Nonpulsed versus pulsed infusions. / Matsumoto, A. H.; Barth, K. H.; Lutz, R. J.; Miller, D. L.

In: Radiology, Vol. 170, No. 3 II, 1989, p. 1077-1080.

Research output: Contribution to journalArticle

Matsumoto, AH, Barth, KH, Lutz, RJ & Miller, DL 1989, 'Hepatic artery model for evaluating the distribution of intraarterial chemotherapy infusion: Nonpulsed versus pulsed infusions', Radiology, vol. 170, no. 3 II, pp. 1077-1080.
Matsumoto, A. H. ; Barth, K. H. ; Lutz, R. J. ; Miller, D. L. / Hepatic artery model for evaluating the distribution of intraarterial chemotherapy infusion : Nonpulsed versus pulsed infusions. In: Radiology. 1989 ; Vol. 170, No. 3 II. pp. 1077-1080.
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