TY - JOUR
T1 - Hepatectomy for noncolorectal non-neuroendocrine metastatic cancer
T2 - A multi-institutional analysis
AU - Groeschl, Ryan T.
AU - Nachmany, Ido
AU - Steel, Jennifer L.
AU - Reddy, Srinevas K.
AU - Glazer, Evan S.
AU - De Jong, Mechteld C.
AU - Pawlik, Timothy M.
AU - Geller, David A.
AU - Tsung, Allan
AU - Marsh, J. Wallis
AU - Clary, Bryan M.
AU - Curley, Steven A.
AU - Gamblin, T. Clark
PY - 2012/5
Y1 - 2012/5
N2 - Background: Although hepatic metastasectomy is well established for colorectal and neuroendocrine cancer, the approach to hepatic metastases from other sites is not well defined. We sought to examine the management of noncolorectal non-neuroendocrine liver metastases. Study Design: A retrospective review from 4 major liver centers identified patients who underwent liver resection for noncolorectal non-neuroendocrine metastases between 1990 and 2009. The Kaplan-Meier method was used to analyze survival, and Cox regression models were used to examine prognostic variables. Results: There were 420 patients available for analysis. Breast cancer (n = 115; 27%) was the most common primary malignancy, followed by sarcoma (n = 98; 23%), and genitourinary cancers (n = 92; 22%). Crude postoperative morbidity and mortality rates were 20% and 2%, respectively. Overall median survival was 49 months, and 1, 3, and 5-year Kaplan-Meier survival rates were 73%, 50%, and 31%. Survival was not significantly different between the various primary tumor types. Recurrent disease was found after hepatectomy in 66% of patients. In multivariable models, lymphovascular invasion (p = 0.05) and metastases
AB - Background: Although hepatic metastasectomy is well established for colorectal and neuroendocrine cancer, the approach to hepatic metastases from other sites is not well defined. We sought to examine the management of noncolorectal non-neuroendocrine liver metastases. Study Design: A retrospective review from 4 major liver centers identified patients who underwent liver resection for noncolorectal non-neuroendocrine metastases between 1990 and 2009. The Kaplan-Meier method was used to analyze survival, and Cox regression models were used to examine prognostic variables. Results: There were 420 patients available for analysis. Breast cancer (n = 115; 27%) was the most common primary malignancy, followed by sarcoma (n = 98; 23%), and genitourinary cancers (n = 92; 22%). Crude postoperative morbidity and mortality rates were 20% and 2%, respectively. Overall median survival was 49 months, and 1, 3, and 5-year Kaplan-Meier survival rates were 73%, 50%, and 31%. Survival was not significantly different between the various primary tumor types. Recurrent disease was found after hepatectomy in 66% of patients. In multivariable models, lymphovascular invasion (p = 0.05) and metastases
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U2 - 10.1016/j.jamcollsurg.2011.12.048
DO - 10.1016/j.jamcollsurg.2011.12.048
M3 - Article
C2 - 22425166
AN - SCOPUS:84860216030
SN - 1072-7515
VL - 214
SP - 769
EP - 777
JO - Journal of the American College of Surgeons
JF - Journal of the American College of Surgeons
IS - 5
ER -