Hepatectomy for hepatocellular carcinoma with major portal or hepatic vein invasion: Results of a multicenter study

Timothy M. Pawlik, Ronnie T. Poon, Eddie K. Abdalla, Iwao Ikai, David M. Nagorney, Jacques Belghiti, Reza Kianmanesh, Irene Oi-Lin Ng, Steven A. Curley, Yoshio Yamaoka, Gregory Y. Lauwers, Jean Nicolas Vauthey

Research output: Contribution to journalArticle

Abstract

Background. The role of hepatic resection in patients with hepatocellular carcinoma (HCC) and invasion of a main portal or hepatic vein branch is controversial. We evaluated the efficacy of hepatic resection and the factors affecting survival after resection in such patients. Methods. The records of 102 patients who underwent resection for HCC with major vascular invasion between 1984 and 1999 were reviewed. Prognostic factors were evaluated by univariate and multivariate analysis. Results. The study included 87 men and 15 women. The median age was 59 years. The perioperative mortality rate was 5.9%. Median survival was 11 months (median follow-up, 93 months). The 1-, 3-, and 5-year survival rates were 45%, 17%, and 10%; the longest-living survivor was still alive at 14.8 years. Absence of moderate to severe fibrosis and absence of high nuclear grade were associated with a better 5-year survival rate (23% vs 5%; P =. 001 and 21% vs 9%; P =. 04, respectively). On multivariate analysis, moderate to severe fibrosis remained a significant predictor of both short-term (≤ 6 months) and long-term (>6 months) survival (P

Original languageEnglish (US)
Pages (from-to)403-410
Number of pages8
JournalSurgery
Volume137
Issue number4
DOIs
StatePublished - Apr 2005
Externally publishedYes

Fingerprint

Hepatic Veins
Hepatectomy
Portal Vein
Multicenter Studies
Hepatocellular Carcinoma
Survival
Fibrosis
Multivariate Analysis
Survival Rate
Liver
Blood Vessels
Survivors
Mortality

ASJC Scopus subject areas

  • Surgery

Cite this

Pawlik, T. M., Poon, R. T., Abdalla, E. K., Ikai, I., Nagorney, D. M., Belghiti, J., ... Vauthey, J. N. (2005). Hepatectomy for hepatocellular carcinoma with major portal or hepatic vein invasion: Results of a multicenter study. Surgery, 137(4), 403-410. https://doi.org/10.1016/j.surg.2004.12.012

Hepatectomy for hepatocellular carcinoma with major portal or hepatic vein invasion : Results of a multicenter study. / Pawlik, Timothy M.; Poon, Ronnie T.; Abdalla, Eddie K.; Ikai, Iwao; Nagorney, David M.; Belghiti, Jacques; Kianmanesh, Reza; Oi-Lin Ng, Irene; Curley, Steven A.; Yamaoka, Yoshio; Lauwers, Gregory Y.; Vauthey, Jean Nicolas.

In: Surgery, Vol. 137, No. 4, 04.2005, p. 403-410.

Research output: Contribution to journalArticle

Pawlik, TM, Poon, RT, Abdalla, EK, Ikai, I, Nagorney, DM, Belghiti, J, Kianmanesh, R, Oi-Lin Ng, I, Curley, SA, Yamaoka, Y, Lauwers, GY & Vauthey, JN 2005, 'Hepatectomy for hepatocellular carcinoma with major portal or hepatic vein invasion: Results of a multicenter study', Surgery, vol. 137, no. 4, pp. 403-410. https://doi.org/10.1016/j.surg.2004.12.012
Pawlik, Timothy M. ; Poon, Ronnie T. ; Abdalla, Eddie K. ; Ikai, Iwao ; Nagorney, David M. ; Belghiti, Jacques ; Kianmanesh, Reza ; Oi-Lin Ng, Irene ; Curley, Steven A. ; Yamaoka, Yoshio ; Lauwers, Gregory Y. ; Vauthey, Jean Nicolas. / Hepatectomy for hepatocellular carcinoma with major portal or hepatic vein invasion : Results of a multicenter study. In: Surgery. 2005 ; Vol. 137, No. 4. pp. 403-410.
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AU - Kianmanesh, Reza

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AU - Vauthey, Jean Nicolas

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