Heparin inhibits the growth of astrocytes in vitro

Patricia L. Robertson, Gary W. Goldstein

Research output: Contribution to journalArticlepeer-review

Abstract

Heparin at a concentration of 100 μg/ml, inhibits neonatal rat astrocyte proliferation by 45%, and [3H]thymidine incorporation into DNA by 55% when they are stimulated with 2% fetal bovine serum (FBS) in culture. Higher serum concentrations up to 10% FBS decreased this inhibition to 20% and 29% respectively. Inhibition of [3H]thymidine incorporation by heparin is dose-dependent with maximal inhibition at 100 μg/ml, but 39% inhibition is still seen at 1 μg/ml on stimulation by 5% FBS. Heparin or heparin-like molecules in the extracellular matrix of brain capillary walls may be important in the regulation of astrocyte growth in vivo.

Original languageEnglish (US)
Pages (from-to)341-345
Number of pages5
JournalBrain research
Volume447
Issue number2
DOIs
StatePublished - May 3 1988
Externally publishedYes

Keywords

  • Astrocyte
  • Growth
  • Heparin
  • Inhibition
  • Thymidine incorporation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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