Hemozoin: Oil versus water

John M. Pisciotta, David Sullivan

Research output: Contribution to journalReview articlepeer-review

Abstract

Because the quinolines inhibit heme crystallization within the malaria parasite much work has focused on mechanism of formation and inhibition of hemozoin. Here we review the recent evidence for heme crystallization within lipids in diverse parasites and the new implications of a lipid site of crystallization for drug targeting. Within leukocytes hemozoin can generate toxic radical lipid metabolites, which may alter immune function or reduce deformability of uninfected erythrocytes.

Original languageEnglish (US)
Pages (from-to)89-96
Number of pages8
JournalParasitology International
Volume57
Issue number2
DOIs
StatePublished - Jun 2008

Keywords

  • Heme crystal
  • Hemozoin
  • Lipid
  • Malaria pigment
  • Plasmodium
  • Quinoline
  • Rhodnius
  • Schistosoma

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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