Hemostatic Factors and Subclinical Brain Infarction in a Community-Based Sample: The ARIC Study

Rebecca F Gottesman, C. Cummiskey, L. Chambless, K. K. Wu, N. Aleksic, A. R. Folsom, A. R. Sharrett

Research output: Contribution to journalArticle

Abstract

Background: Previous data are conflicting as to whether imbalance between hemostatic factors is associated with clinical strokes. We evaluated the association between hemostatic factor levels and subclinical lacunar infarcts in a nested sample from a subset of the Atherosclerosis Risk in Communities (ARIC) cohort. Methods: 196 cases without clinical strokes had lacunar infarcts by MRI, and 214 controls without radiographic infarcts were frequency-matched by age group and sex. Logistic regression models were fitted to assess the association between levels of hemostatic markers and case status. Results: In age-, race- and sex-adjusted models, von Willebrand factor (vWF) and D-dimer were positively associated with case status, with odds ratios for the highest vs. lowest tertile of 2.0 (95% CI 1.2-3.6) for vWF and 1.76 (95% CI 1.02-3.0) for D-dimer. Plasminogen had nonsignificant inverse associations with presence of silent lacunar infarcts. Conclusions: vWF and D-dimer were positively associated, and plasminogen was nonsignificantly inversely associated with subclinical radiographic infarct. Further studies on the role of these hemostatic factors in the development of silent lacunar infarcts may help elucidate the mechanisms behind this injury and may even point to potential targets for future intervention.

Original languageEnglish (US)
Pages (from-to)589-594
Number of pages6
JournalCerebrovascular Diseases
Volume28
Issue number6
DOIs
StatePublished - Nov 2009

Fingerprint

Brain Infarction
Lacunar Stroke
Hemostatics
Atherosclerosis
von Willebrand Factor
Plasminogen
Logistic Models
Stroke
Research Design
Age Groups
Odds Ratio
Wounds and Injuries
fibrin fragment D

Keywords

  • Cerebral infarction
  • Epidemiology
  • Hemostatic disorders
  • Lacunar infarction
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Gottesman, R. F., Cummiskey, C., Chambless, L., Wu, K. K., Aleksic, N., Folsom, A. R., & Sharrett, A. R. (2009). Hemostatic Factors and Subclinical Brain Infarction in a Community-Based Sample: The ARIC Study. Cerebrovascular Diseases, 28(6), 589-594. https://doi.org/10.1159/000247603

Hemostatic Factors and Subclinical Brain Infarction in a Community-Based Sample : The ARIC Study. / Gottesman, Rebecca F; Cummiskey, C.; Chambless, L.; Wu, K. K.; Aleksic, N.; Folsom, A. R.; Sharrett, A. R.

In: Cerebrovascular Diseases, Vol. 28, No. 6, 11.2009, p. 589-594.

Research output: Contribution to journalArticle

Gottesman, RF, Cummiskey, C, Chambless, L, Wu, KK, Aleksic, N, Folsom, AR & Sharrett, AR 2009, 'Hemostatic Factors and Subclinical Brain Infarction in a Community-Based Sample: The ARIC Study', Cerebrovascular Diseases, vol. 28, no. 6, pp. 589-594. https://doi.org/10.1159/000247603
Gottesman, Rebecca F ; Cummiskey, C. ; Chambless, L. ; Wu, K. K. ; Aleksic, N. ; Folsom, A. R. ; Sharrett, A. R. / Hemostatic Factors and Subclinical Brain Infarction in a Community-Based Sample : The ARIC Study. In: Cerebrovascular Diseases. 2009 ; Vol. 28, No. 6. pp. 589-594.
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