Hemostatic alterations in inflammatory bowel disease - Response to therapy

Alan M. Lake, John Q. Stauffer, Marie J. Stuart

Research output: Contribution to journalArticlepeer-review


Twelve patients with acute, untreated inflammatory bowel disease (IBD) were followed prospectively for coagulation and platelet function. With no symptomatic coagulopathy, abnormalities were found in all patients. With acute diseases, elevations of fibrinogen (9/12), factor V (8/12), and factor VIII (6/12) were common. Depressions of antithrombin III levels were also observed acutely (8/12). Abnormalities of platelets were both quantitative and qualitative. Thrombocytosis was present (11/12), and abnormalities in the rate and percent platelet aggregation were seen (9/10). During therapy, factors V and VIII, antithrombin III levels, and the quantitative and qualitative platelet abnormalities returned towards normal in direct correlation with sedimentation rate and clinical disease activity.

Original languageEnglish (US)
Pages (from-to)897-902
Number of pages6
JournalThe American Journal of Digestive Diseases
Issue number10
StatePublished - Oct 1978

ASJC Scopus subject areas

  • Gastroenterology

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