Hemostatic alterations in inflammatory bowel disease - Response to therapy

Alan M. Lake, John Q. Stauffer, Marie J. Stuart

Research output: Contribution to journalArticle

Abstract

Twelve patients with acute, untreated inflammatory bowel disease (IBD) were followed prospectively for coagulation and platelet function. With no symptomatic coagulopathy, abnormalities were found in all patients. With acute diseases, elevations of fibrinogen (9/12), factor V (8/12), and factor VIII (6/12) were common. Depressions of antithrombin III levels were also observed acutely (8/12). Abnormalities of platelets were both quantitative and qualitative. Thrombocytosis was present (11/12), and abnormalities in the rate and percent platelet aggregation were seen (9/10). During therapy, factors V and VIII, antithrombin III levels, and the quantitative and qualitative platelet abnormalities returned towards normal in direct correlation with sedimentation rate and clinical disease activity.

Original languageEnglish (US)
Pages (from-to)897-902
Number of pages6
JournalThe American Journal of Digestive Diseases
Volume23
Issue number10
DOIs
StatePublished - Jan 1 1978
Externally publishedYes

Fingerprint

Hemostatics
Inflammatory Bowel Diseases
Blood Platelets
Factor V
Antithrombin III
Factor VIII
Thrombocytosis
Acute Disease
Platelet Aggregation
Fibrinogen
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hemostatic alterations in inflammatory bowel disease - Response to therapy. / Lake, Alan M.; Stauffer, John Q.; Stuart, Marie J.

In: The American Journal of Digestive Diseases, Vol. 23, No. 10, 01.01.1978, p. 897-902.

Research output: Contribution to journalArticle

Lake, Alan M. ; Stauffer, John Q. ; Stuart, Marie J. / Hemostatic alterations in inflammatory bowel disease - Response to therapy. In: The American Journal of Digestive Diseases. 1978 ; Vol. 23, No. 10. pp. 897-902.
@article{97382eb5d8954fd1a36997d378034005,
title = "Hemostatic alterations in inflammatory bowel disease - Response to therapy",
abstract = "Twelve patients with acute, untreated inflammatory bowel disease (IBD) were followed prospectively for coagulation and platelet function. With no symptomatic coagulopathy, abnormalities were found in all patients. With acute diseases, elevations of fibrinogen (9/12), factor V (8/12), and factor VIII (6/12) were common. Depressions of antithrombin III levels were also observed acutely (8/12). Abnormalities of platelets were both quantitative and qualitative. Thrombocytosis was present (11/12), and abnormalities in the rate and percent platelet aggregation were seen (9/10). During therapy, factors V and VIII, antithrombin III levels, and the quantitative and qualitative platelet abnormalities returned towards normal in direct correlation with sedimentation rate and clinical disease activity.",
author = "Lake, {Alan M.} and Stauffer, {John Q.} and Stuart, {Marie J.}",
year = "1978",
month = "1",
day = "1",
doi = "10.1007/BF01072463",
language = "English (US)",
volume = "23",
pages = "897--902",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Plenum Publishers",
number = "10",

}

TY - JOUR

T1 - Hemostatic alterations in inflammatory bowel disease - Response to therapy

AU - Lake, Alan M.

AU - Stauffer, John Q.

AU - Stuart, Marie J.

PY - 1978/1/1

Y1 - 1978/1/1

N2 - Twelve patients with acute, untreated inflammatory bowel disease (IBD) were followed prospectively for coagulation and platelet function. With no symptomatic coagulopathy, abnormalities were found in all patients. With acute diseases, elevations of fibrinogen (9/12), factor V (8/12), and factor VIII (6/12) were common. Depressions of antithrombin III levels were also observed acutely (8/12). Abnormalities of platelets were both quantitative and qualitative. Thrombocytosis was present (11/12), and abnormalities in the rate and percent platelet aggregation were seen (9/10). During therapy, factors V and VIII, antithrombin III levels, and the quantitative and qualitative platelet abnormalities returned towards normal in direct correlation with sedimentation rate and clinical disease activity.

AB - Twelve patients with acute, untreated inflammatory bowel disease (IBD) were followed prospectively for coagulation and platelet function. With no symptomatic coagulopathy, abnormalities were found in all patients. With acute diseases, elevations of fibrinogen (9/12), factor V (8/12), and factor VIII (6/12) were common. Depressions of antithrombin III levels were also observed acutely (8/12). Abnormalities of platelets were both quantitative and qualitative. Thrombocytosis was present (11/12), and abnormalities in the rate and percent platelet aggregation were seen (9/10). During therapy, factors V and VIII, antithrombin III levels, and the quantitative and qualitative platelet abnormalities returned towards normal in direct correlation with sedimentation rate and clinical disease activity.

UR - http://www.scopus.com/inward/record.url?scp=0018084694&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018084694&partnerID=8YFLogxK

U2 - 10.1007/BF01072463

DO - 10.1007/BF01072463

M3 - Article

VL - 23

SP - 897

EP - 902

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

IS - 10

ER -