Hemorrhagic Transformation after Tissue Plasminogen Activator Reperfusion Therapy for Ischemic Stroke: Mechanisms, Models, and Biomarkers

Wei Wang, Mingchang Li, Qianxue Chen, Jian Wang

Research output: Contribution to journalReview articlepeer-review

Abstract

Intracerebral hemorrhagic transformation (HT) is well recognized as a common cause of hemorrhage in patients with ischemic stroke. HT after acute ischemic stroke contributes to early mortality and adversely affects functional recovery. The risk of HT is especially high when patients receive thrombolytic reperfusion therapy with tissue plasminogen activator, the only available treatment for ischemic stroke. Although many important publications address preclinical models of ischemic stroke, there are no current recommendations regarding the conduct of research aimed at understanding the mechanisms and prediction of HT. In this review, we discuss the underlying mechanisms for HT after ischemic stroke, provide an overview of the models commonly used for the study of HT, and discuss biomarkers that might be used for the early detection of this challenging clinical problem.

Original languageEnglish (US)
Pages (from-to)1572-1579
Number of pages8
JournalMolecular Neurobiology
Volume52
Issue number3
DOIs
StatePublished - Dec 1 2015

Keywords

  • Blood-brain barrier
  • Hemorrhagic transformation
  • Ischemic stroke
  • Tissue plasminogen activator

ASJC Scopus subject areas

  • Neurology
  • Cellular and Molecular Neuroscience

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