Hemorrhagic and ischemic stroke in children with cancer

Corina Noje, Kenneth J Cohen, Lori C. Jordan

Research output: Contribution to journalArticle

Abstract

Background Adult survivors of childhood cancer have an increased risk of cerebrovascular disease; little is known about early stroke risk in childhood cancer. Our objectives were to assess stroke prevalence in children with cancer, to establish cancer and stroke type, and to determine if modifiable risk factors for stroke were present. Methods Children with stroke and cancer were compared with all children seen for cancer at a single institution between 2000 and 2009. An International Classification of Disease, 9th version, code search and search of existing pediatric oncology and stroke databases identified children 3 was found in four children, all with intracerebral hemorrhage. Five of seven children with intracerebral hemorrhage had platelets 3. Conclusions Stroke has a prevalence of approximately 1% in children with cancer. Hemorrhagic stroke and ischemic stroke occur with approximately equal frequency; children with leukemia and brain tumors are at greatest risk.

Original languageEnglish (US)
Pages (from-to)237-242
Number of pages6
JournalPediatric Neurology
Volume49
Issue number4
DOIs
StatePublished - Oct 2013

Fingerprint

Stroke
Neoplasms
Cerebral Hemorrhage
Cerebrovascular Disorders
International Classification of Diseases
Brain Neoplasms
Survivors
Leukemia
Blood Platelets
Databases
Pediatrics

Keywords

  • brain tumors
  • leukemia
  • neurotoxicity of therapy
  • pediatric oncology
  • pediatric stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Neurology

Cite this

Hemorrhagic and ischemic stroke in children with cancer. / Noje, Corina; Cohen, Kenneth J; Jordan, Lori C.

In: Pediatric Neurology, Vol. 49, No. 4, 10.2013, p. 237-242.

Research output: Contribution to journalArticle

@article{198bafe22a5d46678eb545a514919567,
title = "Hemorrhagic and ischemic stroke in children with cancer",
abstract = "Background Adult survivors of childhood cancer have an increased risk of cerebrovascular disease; little is known about early stroke risk in childhood cancer. Our objectives were to assess stroke prevalence in children with cancer, to establish cancer and stroke type, and to determine if modifiable risk factors for stroke were present. Methods Children with stroke and cancer were compared with all children seen for cancer at a single institution between 2000 and 2009. An International Classification of Disease, 9th version, code search and search of existing pediatric oncology and stroke databases identified children 3 was found in four children, all with intracerebral hemorrhage. Five of seven children with intracerebral hemorrhage had platelets 3. Conclusions Stroke has a prevalence of approximately 1{\%} in children with cancer. Hemorrhagic stroke and ischemic stroke occur with approximately equal frequency; children with leukemia and brain tumors are at greatest risk.",
keywords = "brain tumors, leukemia, neurotoxicity of therapy, pediatric oncology, pediatric stroke",
author = "Corina Noje and Cohen, {Kenneth J} and Jordan, {Lori C.}",
year = "2013",
month = "10",
doi = "10.1016/j.pediatrneurol.2013.04.009",
language = "English (US)",
volume = "49",
pages = "237--242",
journal = "Pediatric Neurology",
issn = "0887-8994",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Hemorrhagic and ischemic stroke in children with cancer

AU - Noje, Corina

AU - Cohen, Kenneth J

AU - Jordan, Lori C.

PY - 2013/10

Y1 - 2013/10

N2 - Background Adult survivors of childhood cancer have an increased risk of cerebrovascular disease; little is known about early stroke risk in childhood cancer. Our objectives were to assess stroke prevalence in children with cancer, to establish cancer and stroke type, and to determine if modifiable risk factors for stroke were present. Methods Children with stroke and cancer were compared with all children seen for cancer at a single institution between 2000 and 2009. An International Classification of Disease, 9th version, code search and search of existing pediatric oncology and stroke databases identified children 3 was found in four children, all with intracerebral hemorrhage. Five of seven children with intracerebral hemorrhage had platelets 3. Conclusions Stroke has a prevalence of approximately 1% in children with cancer. Hemorrhagic stroke and ischemic stroke occur with approximately equal frequency; children with leukemia and brain tumors are at greatest risk.

AB - Background Adult survivors of childhood cancer have an increased risk of cerebrovascular disease; little is known about early stroke risk in childhood cancer. Our objectives were to assess stroke prevalence in children with cancer, to establish cancer and stroke type, and to determine if modifiable risk factors for stroke were present. Methods Children with stroke and cancer were compared with all children seen for cancer at a single institution between 2000 and 2009. An International Classification of Disease, 9th version, code search and search of existing pediatric oncology and stroke databases identified children 3 was found in four children, all with intracerebral hemorrhage. Five of seven children with intracerebral hemorrhage had platelets 3. Conclusions Stroke has a prevalence of approximately 1% in children with cancer. Hemorrhagic stroke and ischemic stroke occur with approximately equal frequency; children with leukemia and brain tumors are at greatest risk.

KW - brain tumors

KW - leukemia

KW - neurotoxicity of therapy

KW - pediatric oncology

KW - pediatric stroke

UR - http://www.scopus.com/inward/record.url?scp=84884533443&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84884533443&partnerID=8YFLogxK

U2 - 10.1016/j.pediatrneurol.2013.04.009

DO - 10.1016/j.pediatrneurol.2013.04.009

M3 - Article

C2 - 23942224

AN - SCOPUS:84884533443

VL - 49

SP - 237

EP - 242

JO - Pediatric Neurology

JF - Pediatric Neurology

SN - 0887-8994

IS - 4

ER -