Hemorrhage in murine fetuses exposed to pulsed ultrasound

Diane Dalecki, S. Z. Child, C. H. Raeman, Christopher Cox

Research output: Contribution to journalArticle

Abstract

In the late-gestation fetal mouse, exposure to piezoelectric lithotripter fields at amplitudes <1 MPa produced hemorrhages in tissues near developing bone, such as the head and limbs. This study was undertaken to determine if exposure to pulsed ultrasound at diagnostic frequencies produces similar hemorrhages in the late-gestation fetal mouse. On the 18th day of gestation, fetal mice were exposed in utero to pulsed ultrasound with a 10-μs pulse duration and 100-Hz pulse repetition frequency for a total exposure duration of 3 min. Hemorrhages occurred most often to the developing fetal head. At 1.2 MHz, a threshold for hemorrhage to the fetal head was determined at positive exposure pressures of ~ 4 MPa and corresponding negative pressures of ~2.5 MPa. The threshold increased with at least the first power of frequency. Copyright (C) 1999 World Federation for Ultrasound in Medicine and Biology.

Original languageEnglish (US)
Pages (from-to)1139-1144
Number of pages6
JournalUltrasound in Medicine and Biology
Volume25
Issue number7
DOIs
StatePublished - Sep 1999
Externally publishedYes

Fingerprint

hemorrhages
fetuses
Fetus
Hemorrhage
mice
Head
Pregnancy
Pressure
federations
thresholds
limbs
biology
medicine
bones
repetition
pulse duration
Extremities
Medicine
Bone and Bones
Ultrasonic Waves

Keywords

  • Bioeffect
  • Fetus
  • Hemorrhage
  • Mice
  • Pulsed ultrasound

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Hemorrhage in murine fetuses exposed to pulsed ultrasound. / Dalecki, Diane; Child, S. Z.; Raeman, C. H.; Cox, Christopher.

In: Ultrasound in Medicine and Biology, Vol. 25, No. 7, 09.1999, p. 1139-1144.

Research output: Contribution to journalArticle

Dalecki, Diane ; Child, S. Z. ; Raeman, C. H. ; Cox, Christopher. / Hemorrhage in murine fetuses exposed to pulsed ultrasound. In: Ultrasound in Medicine and Biology. 1999 ; Vol. 25, No. 7. pp. 1139-1144.
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