Hemoquant determination of hookworm-related blood loss and its role in iron deficiency in African children

Rebecca J. Stoltzfus, Marco Albonico, Hababu Mohammad Chwaya, Lorenzo Savioli, James Tielsch, Kerry J Schulze, Ray Yip

Research output: Contribution to journalArticle

Abstract

Iron deficiency remains the most prevalent form of human malnutrition, and current interventions to control it have not decreased the global prevalence. Hookworm control activities are becoming more widely implemented, but the importance of these efforts to prevent anemia in populations is not well-defined. We studied the relationships among hookworm infection, intestinal blood loss, and iron status of 203 Zanzibari school children. Helminth infection intensity was quantified by fecal egg counts, and iron deficiency anemia was defined by low hemoglobin and serum ferritin concentrations. Intestinal blood loss was quantified by measuring fetal heme and heme breakdown products as porphyrin, a noninvasive method that has not been used previously to assess hookworm blood loss. Intestinal blood loss was strongly and linearly related to hookworm egg counts. The degree of degradation of fetal heme indicated that blood loss occurred in the upper gastrointestinal tract, compatible with the behavior of hookworms. Trichuris trichiura and Ascaris lumbricoides infections were also common, but did not contribute significantly to intestinal blood loss in this population. The prevalence of iron deficiency anemia increased steadily as hookworm infection intensity and intestinal blood loss increased. In the context of a poor diet, as exists in Zanzibar and many tropical countries, hookworm related blood loss contributes dramatically to anemia. In such contexts, hookworm control is a feasible and essential component of anemia control. Determination of fetal heme is relatively simple and noninvasive and may be a useful tool for measuring the impact of hookworm control activities.

Original languageEnglish (US)
Pages (from-to)399-404
Number of pages6
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume55
Issue number4
StatePublished - 1996

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Ancylostomatoidea
Iron
Heme
Hookworm Infections
Anemia
Iron-Deficiency Anemias
Ovum
Ascaris lumbricoides
Trichuris
Upper Gastrointestinal Tract
Tanzania
Helminths
Porphyrins
Ferritins
Infection
Malnutrition
Population
Hemoglobins
Diet

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Hemoquant determination of hookworm-related blood loss and its role in iron deficiency in African children. / Stoltzfus, Rebecca J.; Albonico, Marco; Chwaya, Hababu Mohammad; Savioli, Lorenzo; Tielsch, James; Schulze, Kerry J; Yip, Ray.

In: American Journal of Tropical Medicine and Hygiene, Vol. 55, No. 4, 1996, p. 399-404.

Research output: Contribution to journalArticle

Stoltzfus, RJ, Albonico, M, Chwaya, HM, Savioli, L, Tielsch, J, Schulze, KJ & Yip, R 1996, 'Hemoquant determination of hookworm-related blood loss and its role in iron deficiency in African children', American Journal of Tropical Medicine and Hygiene, vol. 55, no. 4, pp. 399-404.
Stoltzfus, Rebecca J. ; Albonico, Marco ; Chwaya, Hababu Mohammad ; Savioli, Lorenzo ; Tielsch, James ; Schulze, Kerry J ; Yip, Ray. / Hemoquant determination of hookworm-related blood loss and its role in iron deficiency in African children. In: American Journal of Tropical Medicine and Hygiene. 1996 ; Vol. 55, No. 4. pp. 399-404.
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