Hemophagocytic Lymphohistiocytosis Secondary to T Cell/Histiocyte-rich Large B Cell Lymphoma in an Adolescent Male

Jonathan L. Metts; Sunita I. Park; Michael A. Briones; Frank G. Keller

doi:10.1177/1093526617699137

Hemophagocytic Lymphohistiocytosis Secondary to T Cell/Histiocyte-rich Large B Cell Lymphoma in an Adolescent Male

Jonathan L. Metts, Sunita I. Park, Michael A. Briones, Frank G. Keller

All Children's Hospital

Research output: Contribution to journal › Article › peer-review

Abstract

Hemophagocytic Lymphohistiocytosis (HLH) is a hyperinflammatory disorder that may be encountered as a primary or secondary phenomenon. HLH secondary to lymphoma has been described, more frequently in adults than in children. T-cell/Histiocyte-rich B-cell lymphoma (THRLBCL) is a large B-cell lymphoma that resides in a microenvironment of robust host immune response and has previously been associated with HLH in adults. Here, we describe the first case of HLH secondary to THRLBCL in an adolescent patient.

Original language	English (US)
Pages (from-to)	95-99
Number of pages	5
Journal	Pediatric and Developmental Pathology
Volume	21
Issue number	1
DOIs	https://doi.org/10.1177/1093526617699137
State	Published - Jan 1 2018

Keywords

hematopathology
hemophagocytic lymphohistiocytosis
histiocytosis
lymphoma
oncology
pediatric

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Pathology and Forensic Medicine

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10.1177/1093526617699137

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abstract = "Hemophagocytic Lymphohistiocytosis (HLH) is a hyperinflammatory disorder that may be encountered as a primary or secondary phenomenon. HLH secondary to lymphoma has been described, more frequently in adults than in children. T-cell/Histiocyte-rich B-cell lymphoma (THRLBCL) is a large B-cell lymphoma that resides in a microenvironment of robust host immune response and has previously been associated with HLH in adults. Here, we describe the first case of HLH secondary to THRLBCL in an adolescent patient.",

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AU - Briones, Michael A.

AU - Keller, Frank G.

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AB - Hemophagocytic Lymphohistiocytosis (HLH) is a hyperinflammatory disorder that may be encountered as a primary or secondary phenomenon. HLH secondary to lymphoma has been described, more frequently in adults than in children. T-cell/Histiocyte-rich B-cell lymphoma (THRLBCL) is a large B-cell lymphoma that resides in a microenvironment of robust host immune response and has previously been associated with HLH in adults. Here, we describe the first case of HLH secondary to THRLBCL in an adolescent patient.

KW - hematopathology

KW - hemophagocytic lymphohistiocytosis

KW - histiocytosis

KW - lymphoma

KW - oncology

KW - pediatric

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Hemophagocytic Lymphohistiocytosis Secondary to T Cell/Histiocyte-rich Large B Cell Lymphoma in an Adolescent Male

Abstract

Keywords

ASJC Scopus subject areas

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