Hemoperfusion through albumin-conjugated agarose gel for the treatment of neonatal jaundice in premature rhesus monkeys

Bruce F. Scharschmidt, James F. Martin, Larry J. Shapiro, Paul H. Plotz, Paul D. Berk

Research output: Contribution to journalArticle

Abstract

Hemoperfusion through albumin-conjugated agarose gel (AAG) effectively removes bilirubin (BR) and other albumin-bound materials from whole blood or plasma. We have used this technique to treat neonatal jaundice in premature rhesus monkeys with a specially designated apparatus which permits continuous perfusion through one of four columns arranged in parallel while the others are sequentially washed with saline and regenerated with ethanol. Less than 15 per cent of the animal's blood volume is required in the extracorporeal circuit at any time. Results indicate that (1) compared with five control monkeys which had a peak BR concentration ([BR]) averaging approximately 4 mg./100 ml., six experimental monkeys showed a significant (p

Original languageEnglish (US)
Pages (from-to)101-109
Number of pages9
JournalThe Journal of Laboratory and Clinical Medicine
Volume89
Issue number1
StatePublished - 1977
Externally publishedYes

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Neonatal Jaundice
Hemoperfusion
Macaca mulatta
Bilirubin
Sepharose
Albumins
Gels
Haplorhini
Blood
Blood Volume
Animals
Ethanol
Therapeutics
Perfusion
Plasmas
Networks (circuits)

ASJC Scopus subject areas

  • Medicine(all)
  • Pathology and Forensic Medicine

Cite this

Hemoperfusion through albumin-conjugated agarose gel for the treatment of neonatal jaundice in premature rhesus monkeys. / Scharschmidt, Bruce F.; Martin, James F.; Shapiro, Larry J.; Plotz, Paul H.; Berk, Paul D.

In: The Journal of Laboratory and Clinical Medicine, Vol. 89, No. 1, 1977, p. 101-109.

Research output: Contribution to journalArticle

Scharschmidt, Bruce F. ; Martin, James F. ; Shapiro, Larry J. ; Plotz, Paul H. ; Berk, Paul D. / Hemoperfusion through albumin-conjugated agarose gel for the treatment of neonatal jaundice in premature rhesus monkeys. In: The Journal of Laboratory and Clinical Medicine. 1977 ; Vol. 89, No. 1. pp. 101-109.
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