Hemoglobin redox reactions and oxidatives stress

Joseph M. Rifkind, Nagababu Enika, Somasundaram Ramasamy, Babu Luke Ravi

Research output: Contribution to journalArticle

Abstract

The role of hemoglobin in transporting oxygen is dependent on the reversible binding of oxygen to Fe(II) hemoglobin with molecular oxygen released at reduced oxygen pressures. The partially oxygenated hemoglobin formed with the release of oxygen from hemoglobin is susceptible to redox reactions where the functional Fe(II) heme is oxidized to Fe(III) and the substrate is reduced. In this article, we review two important redox reactions of hemoglobin and discuss the ramifications of these reactions. The reduction of oxygen to superoxide starts a cascade of oxidative reactions, which are a source for red cell-induced oxidative stress. The reduction of nitrite to nitric oxide produces a labile form of nitric oxide that can be a source for oxidative stress, but can also have important physiological functions.

Original languageEnglish (US)
Pages (from-to)234-237
Number of pages4
JournalRedox Report
Volume8
Issue number5
DOIs
StatePublished - 2003
Externally publishedYes

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Oxidative stress
Redox reactions
Oxidation-Reduction
Hemoglobins
Oxidative Stress
Oxygen
Nitric Oxide
Molecular oxygen
Nitrites
Heme
Superoxides
Cells
Pressure
Substrates

ASJC Scopus subject areas

  • Biochemistry

Cite this

Rifkind, J. M., Enika, N., Ramasamy, S., & Ravi, B. L. (2003). Hemoglobin redox reactions and oxidatives stress. Redox Report, 8(5), 234-237. https://doi.org/10.1179/135100003225002817

Hemoglobin redox reactions and oxidatives stress. / Rifkind, Joseph M.; Enika, Nagababu; Ramasamy, Somasundaram; Ravi, Babu Luke.

In: Redox Report, Vol. 8, No. 5, 2003, p. 234-237.

Research output: Contribution to journalArticle

Rifkind, JM, Enika, N, Ramasamy, S & Ravi, BL 2003, 'Hemoglobin redox reactions and oxidatives stress', Redox Report, vol. 8, no. 5, pp. 234-237. https://doi.org/10.1179/135100003225002817
Rifkind, Joseph M. ; Enika, Nagababu ; Ramasamy, Somasundaram ; Ravi, Babu Luke. / Hemoglobin redox reactions and oxidatives stress. In: Redox Report. 2003 ; Vol. 8, No. 5. pp. 234-237.
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