Hemoglobin metabolism in the malaria parasite Plasmodium falciparium

Susan E. Francis, David J. Sullivan, Daniel E. Goldberg

Research output: Contribution to journalReview articlepeer-review

Abstract

Hemoglobin degradation in intraerythrocytic malaria parasites is a vast process that occurs in an acidic digestive vacuole. Proteases that participate in this catabolic pathway have been defined. Studies of protease biosynthesis have revealed unusual targeting and activation mechanisms. Oxygen radicals and heme are released during proteolysis and must be detoxified by dismutation and polymerization, respectively. The quinoline antimalarials appear to act by preventing sequestration of this toxic heme. Understanding the disposition of hemoglobin has allowed identification of essential processes and metabolic weakpoints that can be exploited to combat this scourge of mankind.

Original languageEnglish (US)
Pages (from-to)97-123
Number of pages27
JournalAnnual review of microbiology
Volume51
DOIs
StatePublished - 1997
Externally publishedYes

Keywords

  • Falcipain
  • Heme
  • Plasmepsin
  • Protease
  • Quinoline

ASJC Scopus subject areas

  • Microbiology

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