Hemoglobin Levels and Skeletal Muscle

Results from the InCHIANTI Study

Matteo Cesari, Brenda W J H Penninx, Fulvio Lauretani, Cosimo R. Russo, Christy Carter, Stefania Bandinelli, Hal Atkinson, Graziano Onder, Marco Pahor, Luigi Ferrucci

Research output: Contribution to journalArticle

Abstract

Background. Anemia is associated with reduced physical performance and muscle strength. The aim of the study was to explore whether anemia and hemoglobin levels are associated with differences in quantitative and qualitative measures of muscle and fat. Methods. The study sample consisted of 909 participants 65 years and older enrolled in the "Invecchiare in Chianti" (InCHIANTI) study, a prospective population-based study of older people aimed at identifying risk factors for late-life disability. All the analyses were performed considering continuous hemoglobin levels as well as the dichotomous anemia variable (defined according to World Health Organization criteria as hemoglobin <12 g/dL in women and <13 g/dL in men). A peripheral quantitative computed tomography (pQCT) scan was performed in all participants to evaluate total, muscular, and fat cross-sectional areas of the calf and relative muscle density. Ankle extension strength was measured using a hand-held dynamometer. Linear regression analyses were used to assess the multivariate relationship of pQCT and skeletal muscle strength measures with hemoglobin levels and anemia after adjustment for demographics, chronic conditions, medication use, and other biological variables. Results. Participants were aged 74.8 ± 6.8 years. In our sample, 94 participants (10.3%) were anemic. Hemoglobin levels were significantly associated with muscle density (β = 0.225 [SE, standard error 0.098], p =.02), muscle area/total area ratio (β = 0.778 [SE 0.262], p = .003), fat area/total area ratio (β = -0.869 [SE 0.225]; p <.001). Skeletal muscle strength and muscle density were highly associated with anemia (β = -3.266 [SE 1.173], p = .005 and β = -0.816 [SE 0.374], p = .03, respectively). Results did not change when analyses were rerun in a restricted sample of participants not affected by major medical conditions. Conclusion. The present study shows that hemoglobin levels are associated with the parameters of body composition obtained by pQCT, and that decreases in muscular strength measures occur in the presence of anemia.

Original languageEnglish (US)
Pages (from-to)249-254
Number of pages6
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume59
Issue number3
StatePublished - Mar 2004
Externally publishedYes

Fingerprint

Anemia
Hemoglobins
Skeletal Muscle
Muscle Strength
Muscles
Fats
Tomography
Specific Gravity
Body Composition
Ankle
Linear Models
Hand
Regression Analysis
Demography
Prospective Studies
Population

ASJC Scopus subject areas

  • Aging

Cite this

Cesari, M., Penninx, B. W. J. H., Lauretani, F., Russo, C. R., Carter, C., Bandinelli, S., ... Ferrucci, L. (2004). Hemoglobin Levels and Skeletal Muscle: Results from the InCHIANTI Study. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 59(3), 249-254.

Hemoglobin Levels and Skeletal Muscle : Results from the InCHIANTI Study. / Cesari, Matteo; Penninx, Brenda W J H; Lauretani, Fulvio; Russo, Cosimo R.; Carter, Christy; Bandinelli, Stefania; Atkinson, Hal; Onder, Graziano; Pahor, Marco; Ferrucci, Luigi.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 59, No. 3, 03.2004, p. 249-254.

Research output: Contribution to journalArticle

Cesari, M, Penninx, BWJH, Lauretani, F, Russo, CR, Carter, C, Bandinelli, S, Atkinson, H, Onder, G, Pahor, M & Ferrucci, L 2004, 'Hemoglobin Levels and Skeletal Muscle: Results from the InCHIANTI Study', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 59, no. 3, pp. 249-254.
Cesari M, Penninx BWJH, Lauretani F, Russo CR, Carter C, Bandinelli S et al. Hemoglobin Levels and Skeletal Muscle: Results from the InCHIANTI Study. Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2004 Mar;59(3):249-254.
Cesari, Matteo ; Penninx, Brenda W J H ; Lauretani, Fulvio ; Russo, Cosimo R. ; Carter, Christy ; Bandinelli, Stefania ; Atkinson, Hal ; Onder, Graziano ; Pahor, Marco ; Ferrucci, Luigi. / Hemoglobin Levels and Skeletal Muscle : Results from the InCHIANTI Study. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2004 ; Vol. 59, No. 3. pp. 249-254.
@article{31995253037c45fcb148a9b32e6fbf97,
title = "Hemoglobin Levels and Skeletal Muscle: Results from the InCHIANTI Study",
abstract = "Background. Anemia is associated with reduced physical performance and muscle strength. The aim of the study was to explore whether anemia and hemoglobin levels are associated with differences in quantitative and qualitative measures of muscle and fat. Methods. The study sample consisted of 909 participants 65 years and older enrolled in the {"}Invecchiare in Chianti{"} (InCHIANTI) study, a prospective population-based study of older people aimed at identifying risk factors for late-life disability. All the analyses were performed considering continuous hemoglobin levels as well as the dichotomous anemia variable (defined according to World Health Organization criteria as hemoglobin <12 g/dL in women and <13 g/dL in men). A peripheral quantitative computed tomography (pQCT) scan was performed in all participants to evaluate total, muscular, and fat cross-sectional areas of the calf and relative muscle density. Ankle extension strength was measured using a hand-held dynamometer. Linear regression analyses were used to assess the multivariate relationship of pQCT and skeletal muscle strength measures with hemoglobin levels and anemia after adjustment for demographics, chronic conditions, medication use, and other biological variables. Results. Participants were aged 74.8 ± 6.8 years. In our sample, 94 participants (10.3{\%}) were anemic. Hemoglobin levels were significantly associated with muscle density (β = 0.225 [SE, standard error 0.098], p =.02), muscle area/total area ratio (β = 0.778 [SE 0.262], p = .003), fat area/total area ratio (β = -0.869 [SE 0.225]; p <.001). Skeletal muscle strength and muscle density were highly associated with anemia (β = -3.266 [SE 1.173], p = .005 and β = -0.816 [SE 0.374], p = .03, respectively). Results did not change when analyses were rerun in a restricted sample of participants not affected by major medical conditions. Conclusion. The present study shows that hemoglobin levels are associated with the parameters of body composition obtained by pQCT, and that decreases in muscular strength measures occur in the presence of anemia.",
author = "Matteo Cesari and Penninx, {Brenda W J H} and Fulvio Lauretani and Russo, {Cosimo R.} and Christy Carter and Stefania Bandinelli and Hal Atkinson and Graziano Onder and Marco Pahor and Luigi Ferrucci",
year = "2004",
month = "3",
language = "English (US)",
volume = "59",
pages = "249--254",
journal = "Journals of Gerontology - Series A Biological Sciences and Medical Sciences",
issn = "1079-5006",
publisher = "Oxford University Press",
number = "3",

}

TY - JOUR

T1 - Hemoglobin Levels and Skeletal Muscle

T2 - Results from the InCHIANTI Study

AU - Cesari, Matteo

AU - Penninx, Brenda W J H

AU - Lauretani, Fulvio

AU - Russo, Cosimo R.

AU - Carter, Christy

AU - Bandinelli, Stefania

AU - Atkinson, Hal

AU - Onder, Graziano

AU - Pahor, Marco

AU - Ferrucci, Luigi

PY - 2004/3

Y1 - 2004/3

N2 - Background. Anemia is associated with reduced physical performance and muscle strength. The aim of the study was to explore whether anemia and hemoglobin levels are associated with differences in quantitative and qualitative measures of muscle and fat. Methods. The study sample consisted of 909 participants 65 years and older enrolled in the "Invecchiare in Chianti" (InCHIANTI) study, a prospective population-based study of older people aimed at identifying risk factors for late-life disability. All the analyses were performed considering continuous hemoglobin levels as well as the dichotomous anemia variable (defined according to World Health Organization criteria as hemoglobin <12 g/dL in women and <13 g/dL in men). A peripheral quantitative computed tomography (pQCT) scan was performed in all participants to evaluate total, muscular, and fat cross-sectional areas of the calf and relative muscle density. Ankle extension strength was measured using a hand-held dynamometer. Linear regression analyses were used to assess the multivariate relationship of pQCT and skeletal muscle strength measures with hemoglobin levels and anemia after adjustment for demographics, chronic conditions, medication use, and other biological variables. Results. Participants were aged 74.8 ± 6.8 years. In our sample, 94 participants (10.3%) were anemic. Hemoglobin levels were significantly associated with muscle density (β = 0.225 [SE, standard error 0.098], p =.02), muscle area/total area ratio (β = 0.778 [SE 0.262], p = .003), fat area/total area ratio (β = -0.869 [SE 0.225]; p <.001). Skeletal muscle strength and muscle density were highly associated with anemia (β = -3.266 [SE 1.173], p = .005 and β = -0.816 [SE 0.374], p = .03, respectively). Results did not change when analyses were rerun in a restricted sample of participants not affected by major medical conditions. Conclusion. The present study shows that hemoglobin levels are associated with the parameters of body composition obtained by pQCT, and that decreases in muscular strength measures occur in the presence of anemia.

AB - Background. Anemia is associated with reduced physical performance and muscle strength. The aim of the study was to explore whether anemia and hemoglobin levels are associated with differences in quantitative and qualitative measures of muscle and fat. Methods. The study sample consisted of 909 participants 65 years and older enrolled in the "Invecchiare in Chianti" (InCHIANTI) study, a prospective population-based study of older people aimed at identifying risk factors for late-life disability. All the analyses were performed considering continuous hemoglobin levels as well as the dichotomous anemia variable (defined according to World Health Organization criteria as hemoglobin <12 g/dL in women and <13 g/dL in men). A peripheral quantitative computed tomography (pQCT) scan was performed in all participants to evaluate total, muscular, and fat cross-sectional areas of the calf and relative muscle density. Ankle extension strength was measured using a hand-held dynamometer. Linear regression analyses were used to assess the multivariate relationship of pQCT and skeletal muscle strength measures with hemoglobin levels and anemia after adjustment for demographics, chronic conditions, medication use, and other biological variables. Results. Participants were aged 74.8 ± 6.8 years. In our sample, 94 participants (10.3%) were anemic. Hemoglobin levels were significantly associated with muscle density (β = 0.225 [SE, standard error 0.098], p =.02), muscle area/total area ratio (β = 0.778 [SE 0.262], p = .003), fat area/total area ratio (β = -0.869 [SE 0.225]; p <.001). Skeletal muscle strength and muscle density were highly associated with anemia (β = -3.266 [SE 1.173], p = .005 and β = -0.816 [SE 0.374], p = .03, respectively). Results did not change when analyses were rerun in a restricted sample of participants not affected by major medical conditions. Conclusion. The present study shows that hemoglobin levels are associated with the parameters of body composition obtained by pQCT, and that decreases in muscular strength measures occur in the presence of anemia.

UR - http://www.scopus.com/inward/record.url?scp=12144288921&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=12144288921&partnerID=8YFLogxK

M3 - Article

VL - 59

SP - 249

EP - 254

JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

SN - 1079-5006

IS - 3

ER -