Hemoglobin is a late event in the differentiation of friend erythroleukemic cells in-vitro. i. the role of interferon-induced proteins

F. Lejbkowicz, B. Trink, S. David, E. Ilan, S. Salzberg

Research output: Contribution to journalArticle

Abstract

Here we report that the interferon (EFN)-induced proteins, 2'-5'-oligoadenylate synthetase (OAS) and IFN-induced protein kinase (PKI), appearance and activity precede that of hemoglobin (Hb) in the differentiation process of Friend erythroleukemic cells (FLC). Since our results are correlative, we assume that OAS and PKI are activated, and act at an early stage in the differentiation process, enabling the late onset of Hb synthesis. It is, thus, suggested that red blood cells harboring specific differentiating genes may be used as more efficient carriers of oxygen-binding molecules.

Original languageEnglish (US)
Pages (from-to)769-775
Number of pages7
JournalArtificial Cells, Blood Substitutes, and Biotechnology
Volume22
Issue number3
DOIs
StatePublished - Jan 1994

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering

Fingerprint Dive into the research topics of 'Hemoglobin is a late event in the differentiation of friend erythroleukemic cells in-vitro. i. the role of interferon-induced proteins'. Together they form a unique fingerprint.

  • Cite this