Hemoglobin e and glucose-6-phosphate dehydrogenase deficiency and plasmodium falciparum malaria in the chittagong hill districts of Bangladesh

Kerry L. Shannon, Sabeena Ahmed, Hafizur Rahman, Chai S. Prue, Jacob Khyang, Malathi Ram, M. Zahirul Haq, Ashish Chowdhury, Jasmin Akter, Gregory E. Glass, Timothy Shields, Myaing M. Nyunt, Wasif A. Khan, David A. Sack, David J. Sullivan

Research output: Contribution to journalArticle

Abstract

Hemoglobin E is largely confined to south and southeast Asia. The association between hemoglobin E (HbE) and malaria is less clear than that of hemoglobin S and C. As part of a malaria study in the Chittagong Hill Districts of Bangladesh, an initial random sample of 202 individuals showed that 39% and 49% of Marma and Khyang ethnic groups, respectively, were positive for either heterozygous or homozygous hemoglobin E. In this group, 6.4% were also found to be severely deficient and 35% mildly deficient for glucose-6-phosphate dehydrogenase (G6PD). In a separate Plasmodium falciparum malaria case-uninfected control study, the odds of having homozygous hemoglobin E (HbEE) compared with normal hemoglobin (HbAA) were higher among malaria cases detected by passive surveillance than age and location matched uninfected controls (odds ratio [OR] = 5.0, 95% confidence interval [CI] = 1.07-46.93). The odds of heterozygous hemoglobin E (HbAE) compared with HbAA were similar between malaria cases and uninfected controls (OR = 0.71, 95% CI = 0.42-1.19). No association by hemoglobin type was found in the initial parasite density or the proportion parasite negative after 2 days of artemether/lumefantrine treatment. HbEE, but not HbAE status was associated with increased passive case detection of malaria.

Original languageEnglish (US)
Pages (from-to)281-286
Number of pages6
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume93
Issue number2
DOIs
StatePublished - Aug 1 2015

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Hemoglobin e and glucose-6-phosphate dehydrogenase deficiency and plasmodium falciparum malaria in the chittagong hill districts of Bangladesh'. Together they form a unique fingerprint.

  • Cite this