TY - JOUR
T1 - Hemoglobin a Synthesis in the Developing Fetus
AU - Kazazian, Haig H.
AU - Woodhead, Andrea P.
PY - 1973/7/12
Y1 - 1973/7/12
N2 - To determine when synthesis of hemoglobin A (composed of 2 α and 2 β chains and the hemoglobin predominant in the human adult) begins in the fetus, hemoglobin synthesis was measured in fetuses of various gestational ages. Synthesis of hemoglobin A by reticulocytes obtained from 42 embryos and fetuses 3.5 to 20.0 cm in crown-to-rump length accounted for 4.3 to 13.0 per cent of total hemoglobin synthesis, and varied directly with fetal crown-to-rump length. Since the smallest embryo was estimated to be 55 days old, β-chain synthesis has begun by that gestational age. Furthermore, since β thalassemia is characterized by decreased β-chain synthesis, the accurate diagnosis of this condition in fetuses depends on knowledge of the values for hemoglobin A synthesis in normal fetuses of variousgestational ages. (N Engl J Med 289:58–62, 1973).
AB - To determine when synthesis of hemoglobin A (composed of 2 α and 2 β chains and the hemoglobin predominant in the human adult) begins in the fetus, hemoglobin synthesis was measured in fetuses of various gestational ages. Synthesis of hemoglobin A by reticulocytes obtained from 42 embryos and fetuses 3.5 to 20.0 cm in crown-to-rump length accounted for 4.3 to 13.0 per cent of total hemoglobin synthesis, and varied directly with fetal crown-to-rump length. Since the smallest embryo was estimated to be 55 days old, β-chain synthesis has begun by that gestational age. Furthermore, since β thalassemia is characterized by decreased β-chain synthesis, the accurate diagnosis of this condition in fetuses depends on knowledge of the values for hemoglobin A synthesis in normal fetuses of variousgestational ages. (N Engl J Med 289:58–62, 1973).
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U2 - 10.1056/NEJM197307122890202
DO - 10.1056/NEJM197307122890202
M3 - Article
C2 - 4710406
AN - SCOPUS:0015921737
SN - 0028-4793
VL - 289
SP - 58
EP - 62
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 2
ER -