Hemoglobin a Synthesis in the Developing Fetus

Haig H. Kazazian, Andrea P. Woodhead

Research output: Contribution to journalArticlepeer-review

Abstract

To determine when synthesis of hemoglobin A (composed of 2 α and 2 β chains and the hemoglobin predominant in the human adult) begins in the fetus, hemoglobin synthesis was measured in fetuses of various gestational ages. Synthesis of hemoglobin A by reticulocytes obtained from 42 embryos and fetuses 3.5 to 20.0 cm in crown-to-rump length accounted for 4.3 to 13.0 per cent of total hemoglobin synthesis, and varied directly with fetal crown-to-rump length. Since the smallest embryo was estimated to be 55 days old, β-chain synthesis has begun by that gestational age. Furthermore, since β thalassemia is characterized by decreased β-chain synthesis, the accurate diagnosis of this condition in fetuses depends on knowledge of the values for hemoglobin A synthesis in normal fetuses of variousgestational ages. (N Engl J Med 289:58–62, 1973).

Original languageEnglish (US)
Pages (from-to)58-62
Number of pages5
JournalNew England Journal of Medicine
Volume289
Issue number2
DOIs
StatePublished - Jul 12 1973

ASJC Scopus subject areas

  • Medicine(all)

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