Hemodynamic effects of intra-arterial infusions of catecholamines on the canine gastric circulation

Michael J. Zinner, John C. Kerr, David G. Reynolds

Research output: Contribution to journalArticle

Abstract

The effects of intra-arterial infusions of epinephrine, norepinephrine, and isoproterenol upon right and left gastric blood flow were studied in anesthetized dogs. Blood flow was measured electromagnetically before and after adrenergic blockade. Infusion of epinephrine (0.05 μg Kg.-1 min.-1) resulted in vasoconstriction (-50 ± 6 ml. min.-1) with autoregulatory escape in the right gastric artery (RGA) and constriction (-41 ± 8 ml. min.-1) followed by significant dilation (+ 56 ± 10 ml. min.-1) in the left gastric artery (LGA). Alpha adrenergic blockade with phenoxybenzamine produced only a dilator response in both RGA and LGA to epinephrine infusion and beta adrenergic blockade resulted in a constrictor response with no autoregulatory escape. Norepinephrine infusions produced a constrictor response of similar magnitude as epinephrine but with little evidence of autoregulatory escape in either RGA and LGA. Alpha adrenergic blockade significantly attenuated this response in both circulations. Isoproterenol is a dilator in both circulations and its response is attenuated only by beta adrenergic blockade. This study demonstrates that the canine stomach has two regionally distinct circulations with the fundus and body exhibiting a greater dilator response than the antrum and pylorus.

Original languageEnglish (US)
Pages (from-to)381-388
Number of pages8
JournalSurgery
Volume78
Issue number3
StatePublished - 1975
Externally publishedYes

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Intra Arterial Infusions
Catecholamines
Canidae
Stomach
Hemodynamics
Adrenergic Agents
Arteries
Epinephrine
Isoproterenol
Norepinephrine
Phenoxybenzamine
Pylorus
Vasoconstriction
Constriction
Dilatation
Dogs

ASJC Scopus subject areas

  • Surgery

Cite this

Zinner, M. J., Kerr, J. C., & Reynolds, D. G. (1975). Hemodynamic effects of intra-arterial infusions of catecholamines on the canine gastric circulation. Surgery, 78(3), 381-388.

Hemodynamic effects of intra-arterial infusions of catecholamines on the canine gastric circulation. / Zinner, Michael J.; Kerr, John C.; Reynolds, David G.

In: Surgery, Vol. 78, No. 3, 1975, p. 381-388.

Research output: Contribution to journalArticle

Zinner, MJ, Kerr, JC & Reynolds, DG 1975, 'Hemodynamic effects of intra-arterial infusions of catecholamines on the canine gastric circulation', Surgery, vol. 78, no. 3, pp. 381-388.
Zinner, Michael J. ; Kerr, John C. ; Reynolds, David G. / Hemodynamic effects of intra-arterial infusions of catecholamines on the canine gastric circulation. In: Surgery. 1975 ; Vol. 78, No. 3. pp. 381-388.
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