Hemodynamic dependence of myocardial oxygen consumption indexes

Jochen D. Schipke, Daniel Burkhoff, David A. Kass, Joe Alexander, Jochen Schaefer, Kiichi Sagawa

Research output: Contribution to journalArticlepeer-review

Abstract

We tested the afterload and contractile state dependency of three indexes of myocardial oxygen consumption (MV̇O2): total energy requirement (E(t)), pressure work index (PWI), and pressure-volume area (PVA). MV̇O2 was measured in seven isolated canine hearts at four or five different end-diastolic volumes at each of three settings of afterload resistance and with the hearts contracting isovolumically. In several hearts, contractility was also varied by dobutamine infusion. Measured MV̇O2 (M(MV̇O2)) was compared with values predicted (P(MV̇O2)) by each index. There was always a high degree of correlation between M(MV̇O2) and P(MV̇O2) for each of the indexes. However, there was a large degree of variability in the coefficients of the M(MV̇O2)-P(MV̇O2) relation from one heart to another. We also observed a statistically significant influence of both afterload and contractile state on the predictive power of each of the indexes. Thus each index that we tested had shortcomings in being able to predict MV̇O2 accurately over a wide range of hemodynamic conditions.

Original languageEnglish (US)
Pages (from-to)H1281-H1291
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume258
Issue number5 27-5
DOIs
StatePublished - 1990

Keywords

  • Pressure-volume area
  • afterload
  • contractility
  • force-time integral
  • heart rate
  • preload

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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