Hemodynamic changes after visual stimulation and breath holding provide evidence for an uncoupling of cerebral blood flow and volume from oxygen metabolism

Manus J. Donahue, Robert David Stevens, Michiel De Boorder, James J Pekar, Jeroen Hendrikse, Peter C Van Zijl

Research output: Contribution to journalArticle

Abstract

Functional neuroimaging is most commonly performed using the blood-oxygenation-level-dependent (BOLD) approach, which is sensitive to changes in cerebral blood flow (CBF), cerebral blood volume (CBV), and the cerebral metabolic rate of oxygen (CMRO2). However, the precise mechanism by which neuronal activity elicits a hemodynamic response remains controversial. Here, visual stimulation (14 secs flashing checkerboard) and breath-hold (4 secs exhale+14 secs breath hold) experiments were performed in alternating sequence on healthy volunteers using BOLD, CBV-weighted, and CBF-weighted fMRI. After visual stimulation, the BOLD signal persisted for 33±5 secs (n=9) and was biphasic with a negative component (undershoot), whereas CBV and CBF returned to baseline without an undershoot at 20±5 and 20±3 secs, respectively. After breath hold, the BOLD signal returned to baseline (23±7 secs) at the same time (P>0.05) as CBV (21±6 secs) and CBF (18±3 secs), without a poststimulus undershoot. These data suggest that the BOLD undershoot after visual activation reflects a persistent increase in CMRO2. These observations support the view that CBV and CBF responses elicited by neuronal activation are not necessarily coupled to local tissue metabolism.

Original languageEnglish (US)
Pages (from-to)176-185
Number of pages10
JournalJournal of Cerebral Blood Flow and Metabolism
Volume29
Issue number1
DOIs
StatePublished - Jan 2009

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Cerebrovascular Circulation
Breath Holding
Photic Stimulation
Hemodynamics
Oxygen
Functional Neuroimaging
Healthy Volunteers
Magnetic Resonance Imaging
Cerebral Blood Volume

Keywords

  • BOLD
  • Brain function
  • CBF
  • CBV
  • Neurovascular coupling
  • Oxygen metabolism

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Neurology

Cite this

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title = "Hemodynamic changes after visual stimulation and breath holding provide evidence for an uncoupling of cerebral blood flow and volume from oxygen metabolism",
abstract = "Functional neuroimaging is most commonly performed using the blood-oxygenation-level-dependent (BOLD) approach, which is sensitive to changes in cerebral blood flow (CBF), cerebral blood volume (CBV), and the cerebral metabolic rate of oxygen (CMRO2). However, the precise mechanism by which neuronal activity elicits a hemodynamic response remains controversial. Here, visual stimulation (14 secs flashing checkerboard) and breath-hold (4 secs exhale+14 secs breath hold) experiments were performed in alternating sequence on healthy volunteers using BOLD, CBV-weighted, and CBF-weighted fMRI. After visual stimulation, the BOLD signal persisted for 33±5 secs (n=9) and was biphasic with a negative component (undershoot), whereas CBV and CBF returned to baseline without an undershoot at 20±5 and 20±3 secs, respectively. After breath hold, the BOLD signal returned to baseline (23±7 secs) at the same time (P>0.05) as CBV (21±6 secs) and CBF (18±3 secs), without a poststimulus undershoot. These data suggest that the BOLD undershoot after visual activation reflects a persistent increase in CMRO2. These observations support the view that CBV and CBF responses elicited by neuronal activation are not necessarily coupled to local tissue metabolism.",
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AU - Donahue, Manus J.

AU - Stevens, Robert David

AU - De Boorder, Michiel

AU - Pekar, James J

AU - Hendrikse, Jeroen

AU - Van Zijl, Peter C

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