Hemochromatosis (HFE) Gene Variants Are Associated with Increased Mitochondrial DNA Levels During HIV-1 Infection and Antiretroviral Therapy

Asha R. Kallianpur, Mariana Gerschenson, Todd Hulgan, Harpreet Kaur, David B. Clifford, David W. Haas, Deborah G. Murdock, Justin C. McArthur, David C. Samuels, David M. Simpson

Research output: Contribution to journalArticle

Abstract

Some HIV-associated complications involve mitochondrial dysfunction and may be less common in individuals with iron-loading HFE (hemochromatosis gene) variants. We evaluated HFE 845A and 187G alleles in relation to mitochondrial DNA (mtDNA) levels in peripheral blood mononuclear cells from 85 individuals with HIV infection on uninterrupted antiretroviral therapy (ART) for 15 or more consecutive weeks. Carriers of HFE gene variants (N = 24) had significantly higher mtDNA levels than noncarriers (N = 61), after adjusting for age, race, sex, and type of ART [adjusted β-coefficient 297, p-value < .001 for at least one HFE variant], but mtDNA declined among all individuals on study during 48 weeks on ART. Increased cellular mtDNA content may represent a compensatory response to mitochondrial stress that is influenced by iron-loading HFE variants.

Original languageEnglish (US)
Pages (from-to)942-949
Number of pages8
JournalAIDS research and human retroviruses
Volume34
Issue number11
DOIs
StatePublished - Nov 2018

Keywords

  • ART
  • Allele
  • HFE
  • mtDNA

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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    Kallianpur, A. R., Gerschenson, M., Hulgan, T., Kaur, H., Clifford, D. B., Haas, D. W., Murdock, D. G., McArthur, J. C., Samuels, D. C., & Simpson, D. M. (2018). Hemochromatosis (HFE) Gene Variants Are Associated with Increased Mitochondrial DNA Levels During HIV-1 Infection and Antiretroviral Therapy. AIDS research and human retroviruses, 34(11), 942-949. https://doi.org/10.1089/aid.2018.0025