Hemochromatosis (HFE) Gene Variants Are Associated with Increased Mitochondrial DNA Levels During HIV-1 Infection and Antiretroviral Therapy

Asha R. Kallianpur; Mariana Gerschenson; Todd Hulgan; Harpreet Kaur; David B. Clifford; David W. Haas; Deborah G. Murdock; Justin C. McArthur; David C. Samuels; David M. Simpson

doi:10.1089/aid.2018.0025

Hemochromatosis (HFE) Gene Variants Are Associated with Increased Mitochondrial DNA Levels During HIV-1 Infection and Antiretroviral Therapy

Asha R. Kallianpur, Mariana Gerschenson, Todd Hulgan, Harpreet Kaur, David B. Clifford, David W. Haas, Deborah G. Murdock, Justin C. McArthur, David C. Samuels, David M. Simpson

School of Medicine

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Some HIV-associated complications involve mitochondrial dysfunction and may be less common in individuals with iron-loading HFE (hemochromatosis gene) variants. We evaluated HFE 845A and 187G alleles in relation to mitochondrial DNA (mtDNA) levels in peripheral blood mononuclear cells from 85 individuals with HIV infection on uninterrupted antiretroviral therapy (ART) for 15 or more consecutive weeks. Carriers of HFE gene variants (N = 24) had significantly higher mtDNA levels than noncarriers (N = 61), after adjusting for age, race, sex, and type of ART [adjusted β-coefficient 297, p-value < .001 for at least one HFE variant], but mtDNA declined among all individuals on study during 48 weeks on ART. Increased cellular mtDNA content may represent a compensatory response to mitochondrial stress that is influenced by iron-loading HFE variants.

Original language	English (US)
Pages (from-to)	942-949
Number of pages	8
Journal	AIDS research and human retroviruses
Volume	34
Issue number	11
DOIs	https://doi.org/10.1089/aid.2018.0025
State	Published - Nov 2018

Keywords

ART
Allele
HFE
mtDNA

ASJC Scopus subject areas

Immunology
Virology
Infectious Diseases

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10.1089/aid.2018.0025

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Kallianpur, A. R., Gerschenson, M., Hulgan, T., Kaur, H., Clifford, D. B., Haas, D. W., Murdock, D. G., McArthur, J. C., Samuels, D. C., & Simpson, D. M. (2018). Hemochromatosis (HFE) Gene Variants Are Associated with Increased Mitochondrial DNA Levels During HIV-1 Infection and Antiretroviral Therapy. AIDS research and human retroviruses, 34(11), 942-949. https://doi.org/10.1089/aid.2018.0025

Kallianpur, AR, Gerschenson, M, Hulgan, T, Kaur, H, Clifford, DB, Haas, DW, Murdock, DG, McArthur, JC, Samuels, DC & Simpson, DM 2018, 'Hemochromatosis (HFE) Gene Variants Are Associated with Increased Mitochondrial DNA Levels During HIV-1 Infection and Antiretroviral Therapy', AIDS research and human retroviruses, vol. 34, no. 11, pp. 942-949. https://doi.org/10.1089/aid.2018.0025

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title = "Hemochromatosis (HFE) Gene Variants Are Associated with Increased Mitochondrial DNA Levels During HIV-1 Infection and Antiretroviral Therapy",

abstract = "Some HIV-associated complications involve mitochondrial dysfunction and may be less common in individuals with iron-loading HFE (hemochromatosis gene) variants. We evaluated HFE 845A and 187G alleles in relation to mitochondrial DNA (mtDNA) levels in peripheral blood mononuclear cells from 85 individuals with HIV infection on uninterrupted antiretroviral therapy (ART) for 15 or more consecutive weeks. Carriers of HFE gene variants (N = 24) had significantly higher mtDNA levels than noncarriers (N = 61), after adjusting for age, race, sex, and type of ART [adjusted β-coefficient 297, p-value < .001 for at least one HFE variant], but mtDNA declined among all individuals on study during 48 weeks on ART. Increased cellular mtDNA content may represent a compensatory response to mitochondrial stress that is influenced by iron-loading HFE variants.",

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author = "Kallianpur, {Asha R.} and Mariana Gerschenson and Todd Hulgan and Harpreet Kaur and Clifford, {David B.} and Haas, {David W.} and Murdock, {Deborah G.} and McArthur, {Justin C.} and Samuels, {David C.} and Simpson, {David M.}",

year = "2018",

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doi = "10.1089/aid.2018.0025",

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AU - Kaur, Harpreet

AU - Clifford, David B.

AU - Haas, David W.

AU - Murdock, Deborah G.

AU - McArthur, Justin C.

AU - Samuels, David C.

AU - Simpson, David M.

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AB - Some HIV-associated complications involve mitochondrial dysfunction and may be less common in individuals with iron-loading HFE (hemochromatosis gene) variants. We evaluated HFE 845A and 187G alleles in relation to mitochondrial DNA (mtDNA) levels in peripheral blood mononuclear cells from 85 individuals with HIV infection on uninterrupted antiretroviral therapy (ART) for 15 or more consecutive weeks. Carriers of HFE gene variants (N = 24) had significantly higher mtDNA levels than noncarriers (N = 61), after adjusting for age, race, sex, and type of ART [adjusted β-coefficient 297, p-value < .001 for at least one HFE variant], but mtDNA declined among all individuals on study during 48 weeks on ART. Increased cellular mtDNA content may represent a compensatory response to mitochondrial stress that is influenced by iron-loading HFE variants.

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Hemochromatosis (HFE) Gene Variants Are Associated with Increased Mitochondrial DNA Levels During HIV-1 Infection and Antiretroviral Therapy

Abstract

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ASJC Scopus subject areas

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