TY - JOUR
T1 - Hemochromatosis gene and nonalcoholic fatty liver disease
T2 - A systematic review and meta-analysis
AU - Hernaez, Ruben
AU - Yeung, Edwina
AU - Clark, Jeanne M.
AU - Kowdley, Kris V.
AU - Brancati, Frederick L.
AU - Kao, Wen Hong Linda
N1 - Funding Information:
This work was supported by the following Grants: the American Diabetes Association, Mentor-Based Fellowship Program 7-07-MN-08 (RH, FLB); NIDDK Diabetes Research and Training Center, P60 DK079637 (FLB) and NIDDK Patient Oriented Research in Type 2 Diabetes Grant, K24-DK62222 (FLB); NIH Grant DK-02957 and the Virginia Mason Liver Center of Excellence Fund (KVK); and K01DK067207 (WHLK).
PY - 2011/11
Y1 - 2011/11
N2 - Background & Aims: Previous studies examining the relationship between the C282Y and H63D HFE mutations and presence of nonalcoholic fatty liver disease (NAFLD) have yielded conflicting results. The goal of this study was to systematically evaluate and summarize data on the association between these two variants and the presence of NAFLD. Methods: The authors searched EMBASE and PUBMED from August 1, 1996 to August 12, 2010. Two investigators independently conducted data abstraction. Ethnic specific weighted prevalence was calculated and pooled odds ratios were estimated using the random effects model. Results: From 2542 references, the authors included 16 case-control studies and 14 case-only studies, or 2610 cases and 7298 controls. The majority of the studies came from Caucasian populations (2287 cases and 4275 controls). The weighted prevalence of HFE mutations in cases was comparable to controls. The meta-analysis was restricted to Caucasians only because of the small sample size of non Caucasian participants. The pooled odds ratio for the presence of any HFE genetic variant in cases was 1.03 (95%CI: 0.90, 1.17; I2: 65.8%, 95%CI: 38.5, 81.0). The presence of other genotypes and secondary analyses yielded similar non significant findings. Conclusions: Our systematic review does not support an association between the HFE genetic variants and the presence of NAFLD.
AB - Background & Aims: Previous studies examining the relationship between the C282Y and H63D HFE mutations and presence of nonalcoholic fatty liver disease (NAFLD) have yielded conflicting results. The goal of this study was to systematically evaluate and summarize data on the association between these two variants and the presence of NAFLD. Methods: The authors searched EMBASE and PUBMED from August 1, 1996 to August 12, 2010. Two investigators independently conducted data abstraction. Ethnic specific weighted prevalence was calculated and pooled odds ratios were estimated using the random effects model. Results: From 2542 references, the authors included 16 case-control studies and 14 case-only studies, or 2610 cases and 7298 controls. The majority of the studies came from Caucasian populations (2287 cases and 4275 controls). The weighted prevalence of HFE mutations in cases was comparable to controls. The meta-analysis was restricted to Caucasians only because of the small sample size of non Caucasian participants. The pooled odds ratio for the presence of any HFE genetic variant in cases was 1.03 (95%CI: 0.90, 1.17; I2: 65.8%, 95%CI: 38.5, 81.0). The presence of other genotypes and secondary analyses yielded similar non significant findings. Conclusions: Our systematic review does not support an association between the HFE genetic variants and the presence of NAFLD.
KW - Case-control studies
KW - Hemochromatosis
KW - Iron
KW - Meta-analysis
KW - Steatosis
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U2 - 10.1016/j.jhep.2011.02.013
DO - 10.1016/j.jhep.2011.02.013
M3 - Article
C2 - 21354231
AN - SCOPUS:80054717696
SN - 0168-8278
VL - 55
SP - 1079
EP - 1085
JO - Journal of Hepatology
JF - Journal of Hepatology
IS - 5
ER -