H. K. Holland, J. L. Spivak

Research output: Contribution to journalReview articlepeer-review


This article discusses the pathophysiology and clinical manifestations of idiopathic and secondary hemochromatosis. Pedigree studies documenting the hereditary evidence for hemochromatosis are discussed. Current theories for the molecular mechanisms that result in iron overload are presented. Diagnostic strategies for assessing hemochromatosis and therapeutic modalities are reviewed.

Original languageEnglish (US)
Pages (from-to)831-845
Number of pages15
JournalMedical Clinics of North America
Issue number4
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Medicine(all)


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